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Sowbhagya R, Anupama SK, Bhagyalakshmi D, et al. Modulatory Effects of . J Pharm Bioallied Sci. 2017;9(1):8-15doi: 10.4103/0975-7406.206219.
Sowbhagya, R., Anupama, S. K., Bhagyalakshmi, D., Anand, S., & Ravikiran, T. (2017). Modulatory Effects of . Journal of pharmacy & bioallied sciences, 9(1), 8-15. https://doi.org/10.4103/0975-7406.206219
Sowbhagya, Ramachandregowda, et al. "Modulatory Effects of ." Journal of pharmacy & bioallied sciences vol. 9,1 (2017): 8-15. doi: https://doi.org/10.4103/0975-7406.206219
Sowbhagya R, Anupama SK, Bhagyalakshmi D, Anand S, Ravikiran T. Modulatory Effects of . J Pharm Bioallied Sci. 2017 Jan-Mar;9(1):8-15. doi: 10.4103/0975-7406.206219. PMID: 28584487; PMCID: PMC5450474.
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J Pharm Bioallied Sci. 2017 Jan-Mar;9(1):8-15. doi: 10.4103/0975-7406.206219.

Modulatory Effects of .

Journal of pharmacy & bioallied sciences

Ramachandregowda Sowbhagya, Siddhaghatta Kariyappa Anupama, Dundaiah Bhagyalakshmi, Santosh Anand, Tekupalli Ravikiran

Affiliations

  1. Department of Biotechnology, Jnana Bharathi Campus, Bangalore University, Bengaluru, Karnataka, India.

PMID: 28584487 PMCID: PMC5450474 DOI: 10.4103/0975-7406.206219

Abstract

OBJECTIVE: The present study was aimed to investigate the neuroprotective effects of

MATERIALS AND METHODS: Male Wistar albino rats of 4- and 22-month-old were divided into control and six supplemented groups. The supplemented groups were orally administered with ellagic acid (EA), 4-hydroxyisophthalic acid (4-HIA), and Dh extract for 30 days.

RESULTS: Age-related decrease in antioxidant enzyme activities was noticed. The hippocampus was found to be more vulnerable to OS as seen by the elevation in the OS markers. Supplementation of the Dh extract, EA, and 4-HIA was found to be effective in up-regulating the antioxidant status. However, the extent of up-regulation was more evident in Dh supplemented animals.

CONCLUSION: Our results suggest that Dh extract and its compounds exhibit neuroprotective effects against age-related OS and can be used as a dietary therapeutic intervention for the treatment of neurological disorders.

Keywords: 4-hydroxyisopthalic acid; Decalepis hamiltonii; aging; brain; ellagic acid; oxidative stress

Conflict of interest statement

There are no conflicts of interest.

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