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Kobayashi S, Tomokuni A, Takahashi H, et al. The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma. Gastrointest Tumors. 2017;3(3):141-152doi: 10.1159/000455955.
Kobayashi, S., Tomokuni, A., Takahashi, H., Akita, H., Sugimura, K., Miyoshi, N., Moon, J. H., Yasui, M., Omori, T., Ohue, M., Fujiwara, Y., Yano, M., & Sakon, M. (2017). The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma. Gastrointestinal tumors, 3(3), 141-152. https://doi.org/10.1159/000455955
Kobayashi, Shogo, et al. "The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma." Gastrointestinal tumors vol. 3,3 (2017): 141-152. doi: https://doi.org/10.1159/000455955
Kobayashi S, Tomokuni A, Takahashi H, Akita H, Sugimura K, Miyoshi N, Moon JH, Yasui M, Omori T, Ohue M, Fujiwara Y, Yano M, Sakon M. The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma. Gastrointest Tumors. 2017 Mar;3(3):141-152. doi: 10.1159/000455955. Epub 2017 Feb 08. PMID: 28611981; PMCID: PMC5465674.
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Gastrointest Tumors. 2017 Mar;3(3):141-152. doi: 10.1159/000455955. Epub 2017 Feb 08.

The Clinical Significance of Alpha-Fetoprotein mRNAs in Patients with Hepatocellular Carcinoma.

Gastrointestinal tumors

Shogo Kobayashi, Akira Tomokuni, Hidenori Takahashi, Hirofumi Akita, Keijiro Sugimura, Norikatsu Miyoshi, Jeong Ho Moon, Masayoshi Yasui, Takeshi Omori, Masayuki Ohue, Yoshiyuki Fujiwara, Masahiko Yano, Masato Sakon

Affiliations

  1. Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.

PMID: 28611981 PMCID: PMC5465674 DOI: 10.1159/000455955

Abstract

BACKGROUND/AIMS: Alpha-fetoprotein (AFP) mRNA-expressing cells are candidates for circulating tumor cells in hepatocellular carcinoma. We analyzed portal vein blood, peripheral blood, and peritoneal lavage samples to detect the presence of AFP mRNA-expressing cells, and explored their relationship with metastasis.

METHODS: We measured the AFP mRNA expression in 112 sets of portal vein and peripheral blood samples and 61 peritoneal lavage samples that had been obtained during surgery. We estimated the change in the positive ratio of patients with AFP mRNA, the associated background factors, and the rate of recurrence.

RESULTS: The change in AFP mRNA positivity in the peripheral blood specimens was remarkable, while that in the portal vein blood and peritoneal lavage samples was similar during hepatectomy. Tumor location was the only factor associated with AFP mRNA positivity. The rate of recurrence was higher in the patients who were positive for AFP mRNA than in those who were negative 9-24 months after hepatectomy. During this limited period, the recurrence rate in the AFP mRNA-positive cases was significantly higher than that in the AFP mRNA-negative cases (

CONCLUSION: AFP mRNA positivity in the peripheral blood was elevated after hepatectomy, and the elevation depended on the tumor location. AFP mRNA positivity might contribute to recurrence-free survival 9-24 months after hepatectomy.

Keywords: Alpha-fetoprotein; Hepatectomy; Hepatocellular carcinoma

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