Display options
Cite
Maziad ASA, Torrealba J, Seikaly MG, et al. Renal-Limited "Lupus-Like" Nephritis: How Much of a Lupus?. Case Rep Nephrol Dial. 2017;7(2):43-48doi: 10.1159/000475493.
Maziad, A. S. A., Torrealba, J., Seikaly, M. G., Hassler, J. R., & Hendricks, A. R. (2017). Renal-Limited "Lupus-Like" Nephritis: How Much of a Lupus?. Case reports in nephrology and dialysis, 7(2), 43-48. https://doi.org/10.1159/000475493
Maziad, Asmaa S Abu, et al. "Renal-Limited "Lupus-Like" Nephritis: How Much of a Lupus?." Case reports in nephrology and dialysis vol. 7,2 (2017): 43-48. doi: https://doi.org/10.1159/000475493
Maziad ASA, Torrealba J, Seikaly MG, Hassler JR, Hendricks AR. Renal-Limited "Lupus-Like" Nephritis: How Much of a Lupus?. Case Rep Nephrol Dial. 2017 May 08;7(2):43-48. doi: 10.1159/000475493. eCollection 2017. PMID: 28612005; PMCID: PMC5465519.
Copy Download .nbib Format: NLM
Share it on

Case Rep Nephrol Dial. 2017 May 08;7(2):43-48. doi: 10.1159/000475493. eCollection 2017.

Renal-Limited "Lupus-Like" Nephritis: How Much of a Lupus?.

Case reports in nephrology and dialysis

Asmaa S Abu Maziad, Jose Torrealba, Mouin G Seikaly, Jared R Hassler, Allen R Hendricks

Affiliations

  1. aDivision of Nephrology, Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
  2. bDivision of Nephrology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
  3. cDivision of Renal Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

PMID: 28612005 PMCID: PMC5465519 DOI: 10.1159/000475493

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative antinuclear antibody tests. Our report describes a 5-year-old male who presented with histopathological findings suggestive of lupus nephritis with no clinical signs or symptoms of SLE and negative autoantibodies. He was treated with corticosteroids, mycophenolate mofetil, and monthly intravenous cyclophosphamide. During the 2-year follow-up period, the proteinuria resolved and kidney function improved with continued negative autoantibody workup. This case presents a category of renal-limited "lupus-like" glomerulonephritis which can be challenging to treat and carries a poor prognosis.

Keywords: Antinuclear antibodies; Full-house; Lupus-like nephritis

References

  1. Front Immunol. 2015 May 13;6:228 - PubMed
  2. Lupus. 2009 Dec;18(14):1276-80 - PubMed
  3. Medicine (Baltimore). 1981 Mar;60(2):87-94 - PubMed
  4. J Am Soc Nephrol. 2013 Sep;24(9):1357-66 - PubMed
  5. Nephrol Dial Transplant. 2004 Jun;19(6):1420-6 - PubMed
  6. Pediatr Nephrol. 1999 Oct;13(8):683-7 - PubMed
  7. Nephrol Dial Transplant. 2016 Jun 7;:null - PubMed
  8. Am J Clin Pathol. 1982 Jul;78(1):29-34 - PubMed
  9. Rheumatol Int. 2013 Jan;33(1):219-22 - PubMed
  10. Nephrol Dial Transplant. 2012 Jun;27(6):2337-42 - PubMed
  11. Rheumatol Int. 2007 Jan;27(3):281-4 - PubMed
  12. Kidney Int. 2004 Feb;65(2):521-30 - PubMed
  13. Ren Fail. 2010;32(9):1025-30 - PubMed
  14. N Engl J Med. 2003 Oct 16;349(16):1526-33 - PubMed
  15. Lupus. 2000;9(2):116-9 - PubMed
  16. Pediatr Nephrol. 2003 Feb;18(2):202-3 - PubMed

Publication Types