Display options
Cite
Wild AT, Yamada Y. Treatment Options in Oligometastatic Disease: Stereotactic Body Radiation Therapy - Focus on Colorectal Cancer. Visc Med. 2017;33(1):54-61doi: 10.1159/000454685.
Wild, A. T., & Yamada, Y. (2017). Treatment Options in Oligometastatic Disease: Stereotactic Body Radiation Therapy - Focus on Colorectal Cancer. Visceral medicine, 33(1), 54-61. https://doi.org/10.1159/000454685
Wild, Aaron T, and Yamada, Yoshiya. "Treatment Options in Oligometastatic Disease: Stereotactic Body Radiation Therapy - Focus on Colorectal Cancer." Visceral medicine vol. 33,1 (2017): 54-61. doi: https://doi.org/10.1159/000454685
Wild AT, Yamada Y. Treatment Options in Oligometastatic Disease: Stereotactic Body Radiation Therapy - Focus on Colorectal Cancer. Visc Med. 2017 Mar;33(1):54-61. doi: 10.1159/000454685. Epub 2017 Feb 03. PMID: 28612018; PMCID: PMC5465794.
Copy Download .nbib Format: NLM
Share it on

Visc Med. 2017 Mar;33(1):54-61. doi: 10.1159/000454685. Epub 2017 Feb 03.

Treatment Options in Oligometastatic Disease: Stereotactic Body Radiation Therapy - Focus on Colorectal Cancer.

Visceral medicine

Aaron T Wild, Yoshiya Yamada

Affiliations

  1. Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

PMID: 28612018 PMCID: PMC5465794 DOI: 10.1159/000454685

Abstract

BACKGROUND: Improvements in systemic therapy for metastatic colorectal cancer (CRC) have markedly extended survival, rendering local control of metastases to critical organs of increasing importance, especially in the oligometastatic setting where the disease may not yet have acquired the ability to widely disseminate. While surgical resection remains the gold standard for oligometastases in many organs, stereotactic body radiation therapy (SBRT) presents a non-invasive alternative for achieving local control.

METHODS: A literature review was performed to identify and summarize the findings of key prospective and retrospective studies that have shaped the field of SBRT for oligometastases to the lung, liver, and spine with a focus on oligometastases from CRC in particular.

RESULTS: Modern dose-escalated SBRT regimens can achieve 1-year local control rates of 77-100%, 90-100%, and 81-95% for oligometastases involving the lung, liver, and spine, respectively. Rates of grade 3 or greater toxicity with contemporary SBRT techniques are consistently low at <10% in the lung, <5% in the liver, and <2%/8% for neurologic/non-neurologic toxicity in the spine, respectively.

CONCLUSION: SBRT appears safe and effective for treating oligometastases involving the lung, liver, and spine. Randomized trials comparing SBRT to surgical resection and other local therapeutic modalities for the treatment of CRC oligometastases bear consideration.

Keywords: Colorectal cancer; Gastrointestinal cancer; Oligometastasis; Stereotactic ablative body radiotherapy; Stereotactic body radiation therapy, SBRT

References

  1. Int J Radiat Oncol Biol Phys. 2005 Nov 15;63(4):1010-5 - PubMed
  2. Ann Surg Oncol. 2014 Nov;21(12):3900-8 - PubMed
  3. Rep Pract Oncol Radiother. 2013 Nov 01;18(6):387-96 - PubMed
  4. J Clin Oncol. 1989 Oct;7(10):1407-18 - PubMed
  5. Int J Radiat Oncol Biol Phys. 2004 Sep 1;60(1):186-96 - PubMed
  6. Oncology (Williston Park). 2005 Aug;19(9):1147-54; discussion 1154, 1157-8, 1160 - PubMed
  7. Acta Oncol. 2006;45(7):838-47 - PubMed
  8. Int J Radiat Oncol Biol Phys. 2016 Aug 1;95(5):1399-404 - PubMed
  9. Spine (Phila Pa 1976). 2009 Oct 15;34(22 Suppl):S101-7 - PubMed
  10. Int J Radiat Oncol Biol Phys. 2007 Mar 1;67(3):793-8 - PubMed
  11. J Thorac Cardiovasc Surg. 2011 May;141(5):1218-22 - PubMed
  12. Int J Radiat Oncol Biol Phys. 1986 Apr;12(4):617-24 - PubMed
  13. Lancet Oncol. 2012 Apr;13(4):395-402 - PubMed
  14. Cancer. 2012 Oct 15;118(20):5069-77 - PubMed
  15. Chest. 1999 May;115(5):1441-3 - PubMed
  16. Radiother Oncol. 2009 Jun;91(3):296-300 - PubMed
  17. Oncology. 2009;76(3):212-9 - PubMed
  18. Radiat Oncol. 2006 Aug 20;1:30 - PubMed
  19. Ann Surg. 2005 May;241(5):715-22, discussion 722-4 - PubMed
  20. Radiother Oncol. 2011 Nov;101(2):255-9 - PubMed
  21. Ann Oncol. 2005 Aug;16(8):1311-9 - PubMed
  22. Dig Surg. 2008;25(6):445-60 - PubMed
  23. Acta Oncol. 2006;45(7):831-7 - PubMed
  24. Surgery. 2012 Jun;151(6):860-70 - PubMed
  25. Int J Radiat Oncol Biol Phys. 2008 Jun 1;71(2):484-90 - PubMed
  26. Pract Radiat Oncol. 2016 Mar-Apr;6(2):86-95 - PubMed
  27. Radiother Oncol. 2013 Jun;107(3):409-13 - PubMed
  28. J Clin Oncol. 2009 Apr 1;27(10):1579-84 - PubMed
  29. Int J Radiat Oncol Biol Phys. 2011 Aug 1;80(5):1492-7 - PubMed
  30. Expert Rev Anticancer Ther. 2012 Apr;12(4):495-503 - PubMed
  31. Ann Surg. 2002 Jun;235(6):759-66 - PubMed
  32. Ann Thorac Surg. 2005 Sep;80(3):1040-5 - PubMed
  33. Am J Clin Oncol. 2015 Aug 11;:null - PubMed
  34. J Thorac Oncol. 2010 Jul;5(7):1091-9 - PubMed
  35. J Cancer Res Clin Oncol. 2015 Mar;141(3):543-53 - PubMed
  36. Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):398-403 - PubMed
  37. Int J Radiat Oncol Biol Phys. 2011 Nov 1;81(3):e39-47 - PubMed
  38. Int J Radiat Oncol Biol Phys. 2015 Mar 1;91(3):524-9 - PubMed
  39. Int J Radiat Oncol Biol Phys. 2006 Feb 1;64(2):473-82 - PubMed
  40. Radiother Oncol. 2007 Dec;85(3):435-42 - PubMed
  41. Am J Surg. 1986 Apr;151(4):457-9 - PubMed
  42. Clin Colorectal Cancer. 2017 Mar;16(1):58-64 - PubMed
  43. J Clin Oncol. 2009 Apr 1;27(10):1585-91 - PubMed
  44. J Gastrointest Surg. 2007 Mar;11(3):256-63 - PubMed
  45. J Clin Gastroenterol. 2008 Sep;42(8):945-9 - PubMed
  46. Int J Radiat Oncol Biol Phys. 2004 Aug 1;59(5):1288-94 - PubMed
  47. N Engl J Med. 2004 Jul 22;351(4):337-45 - PubMed
  48. Spine (Phila Pa 1976). 2009 Oct 15;34(22 Suppl):S78-92 - PubMed
  49. Cancer. 1996 Apr 1;77(7):1254-62 - PubMed
  50. Ann Surg Oncol. 2011 Apr;18(4):1081-7 - PubMed
  51. J Neurooncol. 1985;3(1):77-84 - PubMed
  52. Ann Thorac Surg. 2007 Jul;84(1):203-10 - PubMed
  53. J Clin Oncol. 2001 Jan 1;19(1):164-70 - PubMed
  54. Neurology. 1959 Feb;9(2):91-106 - PubMed
  55. Int J Radiat Oncol Biol Phys. 1996 Jan 1;34(1):251-66 - PubMed
  56. J Clin Oncol. 2009 Apr 1;27(10):1572-8 - PubMed
  57. Br J Surg. 1995 Oct;82(10):1397-400 - PubMed
  58. J Neurosurg Spine. 2013 Mar;18(3):207-14 - PubMed
  59. Am J Clin Oncol. 2009 Oct;32(5):515-20 - PubMed
  60. J BUON. 2015 Jan-Feb;20(1):158-65 - PubMed
  61. J Gastroenterol. 1995 Oct;30(5):615-8 - PubMed
  62. J Thorac Oncol. 2007 Jul;2(7 Suppl 3):S94-100 - PubMed
  63. Radiother Oncol. 2009 Jun;91(3):314-24 - PubMed
  64. Int J Radiat Oncol Biol Phys. 1993 Sep 1;27(1):117-23 - PubMed
  65. Arch Surg. 2006 May;141(5):460-6; discussion 466-7 - PubMed
  66. World J Surg. 1995 Jan-Feb;19(1):59-71 - PubMed
  67. Ann Oncol. 2006 Sep;17 (9):1399-403 - PubMed
  68. Ann Surg Oncol. 2013 Feb;20(2):572-9 - PubMed
  69. Ann Surg. 1999 Sep;230(3):309-18; discussion 318-21 - PubMed
  70. Lancet. 2005 Aug 20-26;366(9486):643-8 - PubMed
  71. World J Gastroenterol. 2012 Jan 7;18(1):25-33 - PubMed

Publication Types