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Shen Z, Zhou Y, Qu L, et al. ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat. Biomed Rep. 2017;6(6):649-653doi: 10.3892/br.2017.906.
Shen, Z., Zhou, Y., Qu, L., & Lei, H. (2017). ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat. Biomedical reports, 6(6), 649-653. https://doi.org/10.3892/br.2017.906
Shen, Zhenwei, et al. "ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat." Biomedical reports vol. 6,6 (2017): 649-653. doi: https://doi.org/10.3892/br.2017.906
Shen Z, Zhou Y, Qu L, Lei H. ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat. Biomed Rep. 2017 Jun;6(6):649-653. doi: 10.3892/br.2017.906. Epub 2017 May 08. PMID: 28584636; PMCID: PMC5449963.
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Biomed Rep. 2017 Jun;6(6):649-653. doi: 10.3892/br.2017.906. Epub 2017 May 08.

ATP serves an anti-inflammatory role by enhancing β-defensin-2 response in acute pneumonia of rat.

Biomedical reports

Zhenwei Shen, Yun Zhou, Le Qu, Han Lei

Affiliations

  1. Intensive Care Unit, Shanghai International Medical Center, Shanghai 201318, P.R. China.
  2. Department of Cardiology, Chinese Traditional Medical Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China.
  3. Department of Cadre, Chinese Traditional Medical Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang 830000, P.R. China.
  4. Department of Respiratory Medicine, Shanghai East Hospital, Shanghai 200120, P.R. China.

PMID: 28584636 PMCID: PMC5449963 DOI: 10.3892/br.2017.906

Abstract

The aim of the current study was to evaluate the effect of ATP on the expression of rat β-defensin-2 (rBD-2) in a time-dependent manner, as well as its therapeutic value in an acute pneumonia rat model. A total of 30 rats as a treatment group and 30 as a control group were treated with the same dose of ATP and normal saline, respectively, lung tissues were isolated from rat and expression of rBD-2 mRNA was assessed with reverse transcription-quantitative polymerase chain reaction (RT-qPCR) at 12, 24 and 36 h following treatment. Rats were divided into five groups: The control group treated with normal saline, the

Keywords: ATP; acute pneumonia; cephalosporins; β-defensin-2

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