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Open Forum Infect Dis. 2017 May 29;4(2):ofx065. doi: 10.1093/ofid/ofx065. eCollection 2017.

Successful Pre- and Posttransplant Sofosbuvir-Based Anti-Hepatitis C Virus Treatment in Persons Living With Human Immunodeficiency Virus Infection.

Open forum infectious diseases

Giovanni Guaraldi, Roberto Rossotti, Gabriella Verucchi, Marcello Tavio, Luisa Pasulo, Barbara Beghetto, Giovanni Dolci, Giulia Nardini, Lorenzo Badia, Anna Magliano, Maria Cristina Moioli, Massimo Puoti,

Affiliations

  1. Infectious Diseases Departments of University of Modena, Italy.
  2. ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
  3. University of Bologna, Italy.
  4. Azienda Ospedaliera Universitaria Ospedali Riuniti, Ancona, Italy; and.
  5. Gastroenterology Department ASST Papa Giovanni XXIII, Bergamo, Italy.

PMID: 28584851 PMCID: PMC5451199 DOI: 10.1093/ofid/ofx065

Abstract

This retrospective study reports the data of sofosbuvir-based anti-hepatitis C virus treatment in 24 candidates and 24 recipients of liver transplantation coinfected with human immunodeficiency virus. Sustained virologic response was cumulatively 85% (90% and 100% in those treated with optimal schedules pre- and posttransplant, respectively).

Keywords: HCV; HIV; NS5A inhibitors; liver transplantation; sofosbuvir.

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