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Simioni N, Filippi A, Scardapane M, et al. Efficacy and Safety of Insulin Degludec for Hyperglycemia Management in Noncritical Hospitalized Patients with Diabetes: An Observational Study. Diabetes Ther. 2017;8(4):941-946doi: 10.1007/s13300-017-0271-6.
Simioni, N., Filippi, A., Scardapane, M., Nicolucci, A., Rossi, M. C., & Frison, V. (2017). Efficacy and Safety of Insulin Degludec for Hyperglycemia Management in Noncritical Hospitalized Patients with Diabetes: An Observational Study. Diabetes therapy : research, treatment and education of diabetes and related disorders, 8(4), 941-946. https://doi.org/10.1007/s13300-017-0271-6
Simioni, Natalino, et al. "Efficacy and Safety of Insulin Degludec for Hyperglycemia Management in Noncritical Hospitalized Patients with Diabetes: An Observational Study." Diabetes therapy : research, treatment and education of diabetes and related disorders vol. 8,4 (2017): 941-946. doi: https://doi.org/10.1007/s13300-017-0271-6
Simioni N, Filippi A, Scardapane M, Nicolucci A, Rossi MC, Frison V. Efficacy and Safety of Insulin Degludec for Hyperglycemia Management in Noncritical Hospitalized Patients with Diabetes: An Observational Study. Diabetes Ther. 2017 Aug;8(4):941-946. doi: 10.1007/s13300-017-0271-6. Epub 2017 Jun 05. PMID: 28585180; PMCID: PMC5544608.
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Diabetes Ther. 2017 Aug;8(4):941-946. doi: 10.1007/s13300-017-0271-6. Epub 2017 Jun 05.

Efficacy and Safety of Insulin Degludec for Hyperglycemia Management in Noncritical Hospitalized Patients with Diabetes: An Observational Study.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Natalino Simioni, Alessio Filippi, Marco Scardapane, Antonio Nicolucci, Maria Chiara Rossi, Vera Frison

Affiliations

  1. Department of Medicine, Cittadella Hospital, ULSS15 Alta Padovana, Cittadella, PD, Italy.
  2. CORESEARCH, Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy.
  3. CORESEARCH, Center for Outcomes Research and Clinical Epidemiology, Pescara, Italy. [email protected].

PMID: 28585180 PMCID: PMC5544608 DOI: 10.1007/s13300-017-0271-6

Abstract

INTRODUCTION: To assess the efficacy and safety of insulin degludec administered in a basal-bolus regimen according to the GesTIO protocol in noncritical hospitalized patients with T1DM and T2DM.

METHODS: Mean blood glucose levels (BG) and their standard deviations (SD) at admission vs. discharge were compared in 52 subjects (48.1% ≥75 years) managed through a basal-bolus scheme including degludec. The percentages of patients with BG at target (140-180 mg/dl) or below at discharge and the incidence rate (and the 95% confidence interval for it) of hypoglycemia were assessed.

RESULTS: From admission to discharge, fasting BG decreased from 237 to 153 mg/dl (p < 0.0001) and SD dropped from 125 to 38 mg/dl (p < 0.0001); average BG decreased from 189 to 145 mg/dl (SD dropped from 57 to 32 mg/dl). At discharge, 28.9% had BG at target, while 50.0% had lower levels (average 119.0 ± 14.4 mg/dl). The incidence rate of hypoglycemia was 0.07 (0.05; 0.11) episodes per person-day; 1 out of 27 episodes occurred during the night.

CONCLUSIONS: Degludec in hospitalized, mainly elderly patients is effective and minimizes glucose variability and nocturnal hypoglycemia.

Keywords: Diabetes mellitus; Insulin degludec; Noncritical hospitalized patients

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