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Björk A, Svensson AM, Fard MNP, et al. Type 1 diabetes mellitus and associated risk factors in patients with or without CHD: a case-control study. Cardiol Young. 2017;1-8doi: 10.1017/S1047951117000968.
Björk, A., Svensson, A. M., Fard, M. N. P., Eriksson, P., & Dellborg, M. (2017). Type 1 diabetes mellitus and associated risk factors in patients with or without CHD: a case-control study. Cardiology in the young, 1-8. https://doi.org/10.1017/S1047951117000968
Björk, Anna, et al. "Type 1 diabetes mellitus and associated risk factors in patients with or without CHD: a case-control study." Cardiology in the young vol. (2017): 1-8. doi: https://doi.org/10.1017/S1047951117000968
Björk A, Svensson AM, Fard MNP, Eriksson P, Dellborg M. Type 1 diabetes mellitus and associated risk factors in patients with or without CHD: a case-control study. Cardiol Young. 2017 May 29;1-8. doi: 10.1017/S1047951117000968. Epub 2017 May 29. PMID: 28552077.
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Cardiol Young. 2017 May 29;1-8. doi: 10.1017/S1047951117000968. Epub 2017 May 29.

Type 1 diabetes mellitus and associated risk factors in patients with or without CHD: a case-control study.

Cardiology in the young

Anna Björk, Ann-Marie Svensson, Mir Nabi Pirouzi Fard, Peter Eriksson, Mikael Dellborg

Affiliations

  1. 1Department of Molecular and Clinical Medicine,Sahlgrenska Academy,Institute of Medicine,University of Gothenburg,Gothenburg,Sweden.
  2. 2Centre of Registers Region Västra Götaland,Gothenburg,Sweden.

PMID: 28552077 DOI: 10.1017/S1047951117000968

Abstract

BACKGROUND: Approximately 1% of children are born with CHD, and 90-95% reach adulthood. Increased exposure to infections and stress-strain can contribute to an increased risk of developing type 1 diabetes mellitus. CHD may increase the risk of more serious infections, stress-strain, and increased risk of developing type 1 diabetes mellitus.

METHODS: We analysed the onset of and the risk of mortality and morbidity associated with concurrent CHD in patients with type 1 diabetes mellitus compared with patients with type 1 diabetes mellitus without CHD. The study combined data from the National Diabetes Register and the National Patient Register.

RESULTS: A total of 104 patients with CHD and type 1 diabetes mellitus were matched with 520 controls. Patients with CHD and type 1 diabetes mellitus had an earlier onset of diabetes (13.9 versus 17.4 years, p<0.001), longer duration of diabetes (22.4 versus 18.1 years, p<0.001), higher prevalence of retinopathy (64.0 versus 43.0%, p=0.003), higher creatinine levels (83.5 versus 74.1 µmol/L, p=0.03), higher mortality (16 versus 5%, p=0.002), and after onset of type 1 diabetes mellitus higher rates of co-morbidity (5.28 versus 3.18, p⩽0.01), heart failure (9 versus 2%, p=0.02), and stroke (6 versus 2%, p=0.048) compared with controls.

CONCLUSIONS: From a nationwide register of patients with type 1 diabetes mellitus, the coexistence of CHD and type 1 diabetes mellitus was associated with an earlier onset, a higher frequency of microvascular complications, co-morbidity, and mortality.

Keywords: CHD; complications; mortality; type 1 diabetes mellitus

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