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Uemura J, Nagpal R, Zerbinati N, et al. Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis. Exp Ther Med. 2017;13(6):3075-3080doi: 10.3892/etm.2017.4332.
Uemura, J., Nagpal, R., Zerbinati, N., Singh, B., Marcellino, M., Mohania, D., Marotta, F., He, F., Ayala, A., Kasugai, Y., & Catanzaro, R. (2017). Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis. Experimental and therapeutic medicine, 13(6), 3075-3080. https://doi.org/10.3892/etm.2017.4332
Uemura, Junji, et al. "Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis." Experimental and therapeutic medicine vol. 13,6 (2017): 3075-3080. doi: https://doi.org/10.3892/etm.2017.4332
Uemura J, Nagpal R, Zerbinati N, Singh B, Marcellino M, Mohania D, Marotta F, He F, Ayala A, Kasugai Y, Catanzaro R. Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis. Exp Ther Med. 2017 Jun;13(6):3075-3080. doi: 10.3892/etm.2017.4332. Epub 2017 Apr 12. PMID: 28587382; PMCID: PMC5450604.
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Exp Ther Med. 2017 Jun;13(6):3075-3080. doi: 10.3892/etm.2017.4332. Epub 2017 Apr 12.

Effect of VBC-1814/7J, a poly-phytocompound, on a non-infectious model of pharyngitis.

Experimental and therapeutic medicine

Junji Uemura, Ravinder Nagpal, Nicola Zerbinati, Birbal Singh, Massimiliano Marcellino, Dheeraj Mohania, Francesco Marotta, Fang He, Antonio Ayala, Yasuhiro Kasugai, Roberto Catanzaro

Affiliations

  1. Suheiro Chem-Tech Center, Niigata 950-1447, Japan.
  2. Division of Laboratories for Probiotic Research, Juntendo University Graduate School of Medicine, Tokyo 162-0803, Japan.
  3. CMP-Medical Center and Laboratories, I-27100 Pavia, Italy.
  4. Indian Veterinary Research Institute, Regional Station, Palampur, Himachal Pradesh 176061, India.
  5. ReGenera Research Group for Aging Intervention, I-20154 Milan, Italy.
  6. Animal Biochemistry Division, National Dairy Research Institute, Karnal, Haryana 121001, India.
  7. Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu, Sichuan 610000, P.R. China.
  8. Department of Biochemistry and Molecular Biology, Seville University, I-41000 Seville, Spain.
  9. Department of Internal Medicine, University of Catania, 95121 Catania, Italy.

PMID: 28587382 PMCID: PMC5450604 DOI: 10.3892/etm.2017.4332

Abstract

Pharyngitis presents as an inflammation of the oropharynx, and clinical examination often shows evidence of nasopharyngitis. In numerous cases the condition occurs as a self-limiting illness of non-infectious aetiology, whose clinical management remains a matter for debate given the inappropriateness of antibiotics, the reported worsening following steroid use and the recent discouragement of the use of Chinese herbal medicine. The aim of the present study was thus to test VBC-1814/7J, a poly-phytocompound with known anti-inflammatory and immune-response enhancing properties, in an experimental model of non-infectious pharyngitis. Experimental non-infectious pharyngitis was induced by applying a pyridine solution to the surface of the pharyngeal mucosa in rats that were either normally fed (group A) or fed VBC-1814/7J three days prior to and three days subsequent to the induction of pharyngitis (group B). Healthy rats treated with topical saline were used as a control (group C). At time-points of 0, one hour, one day and three days sacrifices were carried out and microscopic examination, Evans blue (EB) dye extravasation and tissue concentrations of tumour necrosis factor (TNF)-α, interleukin (IL)-6 and mRNA of α- and β-defensins were studied. As compared with group C, group A showed significant microscopic damage, EB extravasation, and increases in the levels of TNF-α and IL-6, as well as in the mRNA of three defensins (P<0.001) on the third day of observation. VBC-1814/7J significantly mitigated these microscopic and inflammatory markers while allowing a prompter and wider defensin reaction (P<0.05 vs. group A). These data suggest that VBC-1814/7J, as demonstrated in earlier studies, has the potential to address non-infectious pharyngitis in clinical practice.

Keywords: non-infectious model of pharyngitis; phytocompound; β-defensins

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