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Eckersten D, Tsatsanis C, Giwercman A, et al. MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease. Nephron Extra. 2017;7(1):33-41doi: 10.1159/000458711.
Eckersten, D., Tsatsanis, C., Giwercman, A., Bruun, L., Pihlsgård, M., & Christensson, A. (2017). MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease. Nephron extra, 7(1), 33-41. https://doi.org/10.1159/000458711
Eckersten, Dag, et al. "MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease." Nephron extra vol. 7,1 (2017): 33-41. doi: https://doi.org/10.1159/000458711
Eckersten D, Tsatsanis C, Giwercman A, Bruun L, Pihlsgård M, Christensson A. MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease. Nephron Extra. 2017 Apr 07;7(1):33-41. doi: 10.1159/000458711. eCollection 2017. PMID: 28553316; PMCID: PMC5423313.
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Nephron Extra. 2017 Apr 07;7(1):33-41. doi: 10.1159/000458711. eCollection 2017.

MicroRNA-155 and Anti-Müllerian Hormone: New Potential Markers of Subfertility in Men with Chronic Kidney Disease.

Nephron extra

Dag Eckersten, Christos Tsatsanis, Aleksander Giwercman, Laila Bruun, Mats Pihlsgård, Anders Christensson

Affiliations

  1. Department of Nephrology, Lund University, Skåne University Hospital, Malmö, Sweden.
  2. Department of Clinical Chemistry, School of Medicine, University of Crete, Heraklion, Crete, Greece.
  3. Molecular Reproductive Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.
  4. Department of Geriatrics, Lund University, Skåne University Hospital, Malmö, Sweden.

PMID: 28553316 PMCID: PMC5423313 DOI: 10.1159/000458711

Abstract

BACKGROUND/AIMS: Men with terminal renal failure are often infertile. Anti-müllerian hormone (AMH), a marker of Sertoli cell function, is decreased among men with chronic kidney disease (CKD). Recently, a microRNA, miR-155, has been shown to be a potential marker for subfertility. We studied miR-155 and semen parameters in patients with CKD who were not yet on dialysis. We also aimed to study possible associations between AMH, miR-155, and semen parameters to evaluate them as markers of fertility.

METHODS: Thirty male patients with CKD 1-4 as well as 18 healthy controls were enrolled.

RESULTS: Serum levels of miR-155 were significantly higher among men with CKD stages 1-2 (4.51 ± 3.81 [

CONCLUSIONS: We conclude that men with stage 3-4 CKD had lower sperm concentrations than healthy fertile men and that increased serum miR-155 in men with stage 1-4 CKD was associated with semen parameters that indicate subfertility. Low AMH levels were associated with a low percentage of the total number of motile sperm cells. miR-155 and AMH may be potential markers of subfertility in men with CKD.

Keywords: Chronic kidney disease; Fertility; Hemodialysis

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