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Slavich M, Patel RS. Coronary artery spasm: Current knowledge and residual uncertainties. Int J Cardiol Heart Vasc. 2016;10:47-53doi: 10.1016/j.ijcha.2016.01.003.
Slavich, M., & Patel, R. S. (2016). Coronary artery spasm: Current knowledge and residual uncertainties. International journal of cardiology. Heart & vasculature, 1047-53. https://doi.org/10.1016/j.ijcha.2016.01.003
Slavich, Massimo, and Patel, Riyaz Suleman. "Coronary artery spasm: Current knowledge and residual uncertainties." International journal of cardiology. Heart & vasculature vol. 10 (2016): 47-53. doi: https://doi.org/10.1016/j.ijcha.2016.01.003
Slavich M, Patel RS. Coronary artery spasm: Current knowledge and residual uncertainties. Int J Cardiol Heart Vasc. 2016 Jan 23;10:47-53. doi: 10.1016/j.ijcha.2016.01.003. eCollection 2016 Mar. PMID: 28616515; PMCID: PMC5462634.
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Int J Cardiol Heart Vasc. 2016 Jan 23;10:47-53. doi: 10.1016/j.ijcha.2016.01.003. eCollection 2016 Mar.

Coronary artery spasm: Current knowledge and residual uncertainties.

International journal of cardiology. Heart & vasculature

Massimo Slavich, Riyaz Suleman Patel

Affiliations

  1. Dept. of Cardiology, The Heart Hospital, University College London NHS Trust, London, UK.
  2. Unità Terapia Intensiva Coronarica, IRCCS Ospedale San Raffale, Via Olgettina 58, Milan, Italy.
  3. Institute of Cardiovascular Sciences, University College London, London, UK.

PMID: 28616515 PMCID: PMC5462634 DOI: 10.1016/j.ijcha.2016.01.003

Abstract

Myocardial ischaemia results from a direct mismatch between oxygen supply and demand, commonly arising as a result of coronary atherosclerosis, microvascular dysfunction or acute thrombosis and luminal obstruction. However, transient ischaemia may also occur due to coronary spasm leading to acute and unexpected myocardial ischaemia without obvious visible coronary pathology. Aside from symptoms of chest pain, coronary spasm can cause infarction, LV impairment, promote life threatening arrhythmias and ultimately sudden cardiac death. While therapeutic options are available, controversies exist around diagnosis, pathology, management and prognosis. This review summarises some of the common questions in this area. In particular we explore and discuss the available evidence for the pharmacological treatment of coronary spasm, and strategies for identification and management of very high risk patients to try and reduce the incidence of sudden premature death.

Keywords: Coronary spasm; Printzmetal angina; Variant angina

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