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Mokos ZB, Jović A, Grgurević L, et al. Current Therapeutic Approach to Hypertrophic Scars. Front Med (Lausanne). 2017;4:83doi: 10.3389/fmed.2017.00083.
Mokos, Z. B., Jović, A., Grgurević, L., Dumić-Čule, I., Kostović, K., Čeović, R., & Marinović, B. (2017). Current Therapeutic Approach to Hypertrophic Scars. Frontiers in medicine, 483. https://doi.org/10.3389/fmed.2017.00083
Mokos, Zrinka Bukvić, et al. "Current Therapeutic Approach to Hypertrophic Scars." Frontiers in medicine vol. 4 (2017): 83. doi: https://doi.org/10.3389/fmed.2017.00083
Mokos ZB, Jović A, Grgurević L, Dumić-Čule I, Kostović K, Čeović R, Marinović B. Current Therapeutic Approach to Hypertrophic Scars. Front Med (Lausanne). 2017 Jun 20;4:83. doi: 10.3389/fmed.2017.00083. eCollection 2017. PMID: 28676850; PMCID: PMC5476971.
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Front Med (Lausanne). 2017 Jun 20;4:83. doi: 10.3389/fmed.2017.00083. eCollection 2017.

Current Therapeutic Approach to Hypertrophic Scars.

Frontiers in medicine

Zrinka Bukvić Mokos, Anamaria Jović, Lovorka Grgurević, Ivo Dumić-Čule, Krešimir Kostović, Romana Čeović, Branka Marinović

Affiliations

  1. Department of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
  2. Laboratory for Mineralized Tissues, School of Medicine, University of Zagreb, Zagreb, Croatia.

PMID: 28676850 PMCID: PMC5476971 DOI: 10.3389/fmed.2017.00083

Abstract

Abnormal scarring and its accompanying esthetic, functional, and psychological sequelae still pose significant challe nges. To date, there is no satisfactory prevention or treatment option for hypertrophic scars (HSs), which is mostly due to not completely comprehending the mechanisms underlying their formation. That is why the apprehension of regular and controlled physiological processes of scar formation is of utmost importance when facing hypertrophic scarring, its pathophysiology, prevention, and therapeutic approach. When treating HSs and choosing the best treatment and prevention modality, physicians can choose from a plethora of therapeutic options and many commercially available products, among which currently there is no efficient option that can successfully overcome impaired skin healing. This article reviews current therapeutic approach and emerging therapeutic strategies for the management of HSs, which should be individualized, based on an evaluation of the scar itself, patients' expectations, and practical, evidence-based guidelines. Clinicians are encouraged to combine various prevention and treatment modalities where combination therapy that includes steroid injections, 5-fluorouracil, and pulsed-dye laser seems to be the most effective. On the other hand, the current therapeutic options are usually empirical and their results are unreliable and unpredictable. Therefore, there is an unmet need for an effective, targeted therapy and prevention, which would be based on an action or a modulation of a particular factor with clarified mechanism of action that has a beneficial effect on wound healing. As the extracellular matrix has a crucial role in cellular and extracellular events that lead to pathological scarring, targeting its components mostly by regulating bone morphogenetic proteins may throw up new therapeutic approach for reduction or prevention of HSs with functionally and cosmetically acceptable outcome.

Keywords: hypertrophic scar; prevention; scar management; skin scarring; topical therapy; treatment; wound healing

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