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Calvello R, Lofrumento DD, Perrone MG, et al. Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both . Front Neurol. 2017;8:251doi: 10.3389/fneur.2017.00251.
Calvello, R., Lofrumento, D. D., Perrone, M. G., Cianciulli, A., Salvatore, R., Vitale, P., De Nuccio, F., Giannotti, L., Nicolardi, G., Panaro, M. A., & Scilimati, A. (2017). Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both . Frontiers in neurology, 8251. https://doi.org/10.3389/fneur.2017.00251
Calvello, Rosa, et al. "Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both ." Frontiers in neurology vol. 8 (2017): 251. doi: https://doi.org/10.3389/fneur.2017.00251
Calvello R, Lofrumento DD, Perrone MG, Cianciulli A, Salvatore R, Vitale P, De Nuccio F, Giannotti L, Nicolardi G, Panaro MA, Scilimati A. Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both . Front Neurol. 2017 Jun 09;8:251. doi: 10.3389/fneur.2017.00251. eCollection 2017. PMID: 28649222; PMCID: PMC5465243.
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Front Neurol. 2017 Jun 09;8:251. doi: 10.3389/fneur.2017.00251. eCollection 2017.

Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac Counteract Inflammatory State both .

Frontiers in neurology

Rosa Calvello, Dario Domenico Lofrumento, Maria Grazia Perrone, Antonia Cianciulli, Rosaria Salvatore, Paola Vitale, Francesco De Nuccio, Laura Giannotti, Giuseppe Nicolardi, Maria Antonietta Panaro, Antonio Scilimati

Affiliations

  1. Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "A. Moro", Bari, Italy.
  2. Department of Biological and Environmental Sciences and Technologies, Section of Human Anatomy, University of Salento, Lecce, Italy.
  3. Department of Pharmacy - Pharmaceutical Sciences, University of Bari "A. Moro", Bari, Italy.

PMID: 28649222 PMCID: PMC5465243 DOI: 10.3389/fneur.2017.00251

Abstract

Activated microglia secrete an array of pro-inflammatory factors, such as prostaglandins, whose accumulation contributes to neuronal damages. Prostaglandin endoperoxide synthases or cyclooxygenases (COX-1 and COX-2), which play a critical role in the inflammation, are the pharmacological targets of non-steroidal anti-inflammatory drugs, used to treat pain and inflammation. Since it was reported that COX-1 is the major player in mediating the brain inflammatory response, the aim of this study was to evaluate the effects of highly selective COX-1 inhibitors, such as P6 and mofezolac, in neuroinflammation models. Lipopolysaccharide (LPS)-activated mouse BV-2 microglial cells and LPS intracerebroventricular-injected mice as

Keywords: P6 and mofezolac; cyclooxygenase-1; cyclooxygenase-1 inhibitors; in vitro and in vivo experiments; lipopolysaccharide-treated BV2 microglial cells; neuroinflammation

References

  1. J Med Chem. 2004 Sep 23;47(20):4881-90 - PubMed
  2. Prostaglandins Other Lipid Mediat. 1998 Jul;56(4):245-54 - PubMed
  3. Prostaglandins Other Lipid Mediat. 2002 Aug;68-69:165-75 - PubMed
  4. Cell. 2010 Mar 19;140(6):918-34 - PubMed
  5. Bioorg Med Chem. 2017 Jan 15;25(2):665-676 - PubMed
  6. Aging (Albany NY). 2009 Feb 11;1(2):234-44 - PubMed
  7. J Neuroinflammation. 2014 Jul 30;11:134 - PubMed
  8. Neuroscience. 2015 Nov 19;309:84-99 - PubMed
  9. Brain Res. 1999 Jun 5;830(2):226-36 - PubMed
  10. Neurogenetics. 2014 Aug;15(3):201-12 - PubMed
  11. J Neurochem. 2010 Jul;114(1):247-58 - PubMed
  12. Med Res Rev. 2016 Jul;36(4):641-71 - PubMed
  13. J Cereb Blood Flow Metab. 2010 Feb;30(2):370-80 - PubMed
  14. Annu Rev Immunol. 2009;27:119-45 - PubMed
  15. Int J Mol Sci. 2016 Jun 30;17 (7): - PubMed
  16. J Nucl Med. 2016 Feb;57(2):291-6 - PubMed
  17. J Neurochem. 2003 Dec;87(6):1518-26 - PubMed
  18. Pharmacol Res. 2012 Jan;65(1):137-48 - PubMed
  19. Glia. 2016 Apr;64(4):635-49 - PubMed
  20. Neuron. 2012 May 24;74(4):691-705 - PubMed
  21. Front Cell Neurosci. 2013 Nov 22;7:229 - PubMed
  22. FASEB J. 2008 May;22(5):1491-501 - PubMed
  23. Biochimie. 2011 Jan;93(1):46-51 - PubMed
  24. Mod Trends Pharmacopsychiatry. 2013;28:175-87 - PubMed
  25. Trends Pharmacol Sci. 2009 Apr;30(4):174-81 - PubMed
  26. Molecules. 2011 Jan 25;16(2):1021-43 - PubMed
  27. Curr Med Chem. 2015;22(37):4271-92 - PubMed
  28. Nature. 2012 May 30;485(7400):570-2 - PubMed
  29. Mol Neurobiol. 2016 Dec;53(10 ):6709-6715 - PubMed
  30. Mol Med Rep. 2014 Oct;10(4):1793-9 - PubMed
  31. Neuron Glia Biol. 2011 Feb;7(1):17-23 - PubMed
  32. Neuroimmunomodulation. 2011;18(2):79-88 - PubMed

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