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NPJ Microgravity. 2017 Feb 28;3:10. doi: 10.1038/s41526-017-0011-2. eCollection 2017.

Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study .

NPJ microgravity

Jennifer Barrila, Jiseon Yang, Aurélie Crabbé, Shameema F Sarker, Yulong Liu, C Mark Ott, Mayra A Nelman-Gonzalez, Simon J Clemett, Seth D Nydam, Rebecca J Forsyth, Richard R Davis, Brian E Crucian, Heather Quiriarte, Kenneth L Roland, Karen Brenneman, Clarence Sams, Christine Loscher, Cheryl A Nickerson

Affiliations

  1. Center for Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, Tempe, AZ USA.
  2. Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium.
  3. Biomedical Research and Environmental Sciences Division, NASA Johnson Space Center, Houston, TX USA.
  4. Wyle Science, Technology and Engineering Group, Houston, TX USA.
  5. ERC, Inc/Jacobs JETS, Houston, TX USA.
  6. JES Tech, Houston, TX USA.
  7. Immunomodulation Research Group, School of Biotechnology, Dublin City University, Glasnevin, Ireland.
  8. School of Life Sciences, Arizona State University, Tempe, AZ USA.

PMID: 28649632 PMCID: PMC5460263 DOI: 10.1038/s41526-017-0011-2

Abstract

Three-dimensional models of human intestinal epithelium mimic the differentiated form and function of parental tissues often not exhibited by two-dimensional monolayers and respond to

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