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Hasija PK, Karloopia SD, Shahi BN, et al. QUANTIFICATION OF EXERCISE TOLERANCE IN CONGESTIVE HEART FAILURE AND ROLE OF ACE INHIBITORS. Med J Armed Forces India. 2017;54(4):331-334doi: 10.1016/S0377-1237(17)30598-1.
Hasija, P. K., Karloopia, S. D., Shahi, B. N., & Chauhan, S. S. (1998). QUANTIFICATION OF EXERCISE TOLERANCE IN CONGESTIVE HEART FAILURE AND ROLE OF ACE INHIBITORS. Medical journal, Armed Forces India, 54(4), 331-334. https://doi.org/10.1016/S0377-1237(17)30598-1
Hasija, P K, et al. "QUANTIFICATION OF EXERCISE TOLERANCE IN CONGESTIVE HEART FAILURE AND ROLE OF ACE INHIBITORS." Medical journal, Armed Forces India vol. 54,4 (1998): 331-334. doi: https://doi.org/10.1016/S0377-1237(17)30598-1
Hasija PK, Karloopia SD, Shahi BN, Chauhan SS. QUANTIFICATION OF EXERCISE TOLERANCE IN CONGESTIVE HEART FAILURE AND ROLE OF ACE INHIBITORS. Med J Armed Forces India. 1998 Oct;54(4):331-334. doi: 10.1016/S0377-1237(17)30598-1. Epub 2017 Jun 26. PMID: 28775524; PMCID: PMC5531643.
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Med J Armed Forces India. 1998 Oct;54(4):331-334. doi: 10.1016/S0377-1237(17)30598-1. Epub 2017 Jun 26.

QUANTIFICATION OF EXERCISE TOLERANCE IN CONGESTIVE HEART FAILURE AND ROLE OF ACE INHIBITORS.

Medical journal, Armed Forces India

P K Hasija, S D Karloopia, B N Shahi, S S Chauhan

Affiliations

  1. Graded Specialist Medicine, Office of the Senior Consultant (Med), Army Hospital Research and Referral, Delhi Cantt- 110 010.
  2. Senior Adviser Medicine and Cardiology, Head of the Department of Medicine, Army Hospital Research and Referral, Delhi Cantt- 110 010.
  3. Commandant, Army Hospital Research and Referral, Delhi Cantt- 110 010.
  4. Consultant Medicine and Cardiology, Army Hospital Research and Referral, Delhi Cantt- 110 010.

PMID: 28775524 PMCID: PMC5531643 DOI: 10.1016/S0377-1237(17)30598-1

Abstract

A prospective randomised controlled trial with captopril/enalapril was carried out on 25 patients with congestive heart failure (CHF) of various aetiologies in NYHA Class II & III to study the effect of Ace inhibitors on exercise tolerance. The control group (Gp-A) comprising of 12 patients received conventional treatment (digitalis and diuretics) and the test group (Gp-B) with 13 patients were in addition given captopril/enalapril as tolerated. They were followed up for a mean period of 101.6+50.6 days (approx 3 months). Ten patients from each group could complete the study. The exercise testing was done on treadmill using a suitable protocol and end-points, at the beginning and end of study. None of the clinical and noninvasive parameters showed significant difference, however the mean exercise duration in Group A improved from 7.84+3.34 to 9.2 +3.16 minute (P <0.05) and in Group B increased from 7.91+4.6 to 10. 92+4.66 minute (p < 0.001). On comparing the benefits of the two groups the difference was statistically significant (P < 0.05). It is concluded that Ace inhibitor improves the exercise tolerance in CHF and the benefit is evident despite any improvement in clinical and noninvasive indices of left ventricular function.

Keywords: Ace-inhibitor; Exercise capacity; Heart failure

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