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Front Neuroanat. 2017 Jul 20;11:60. doi: 10.3389/fnana.2017.00060. eCollection 2017.

Two Subpopulations of Noradrenergic Neurons in the Locus Coeruleus Complex Distinguished by Expression of the Dorsal Neural Tube Marker .

Frontiers in neuroanatomy

Nicholas W Plummer, Erica L Scappini, Kathleen G Smith, Charles J Tucker, Patricia Jensen

Affiliations

  1. Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, United States Department of Health and Human ServicesDurham, NC, United States.
  2. Signal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, United States Department of Health and Human ServicesDurham, NC, United States.

PMID: 28775681 PMCID: PMC5518464 DOI: 10.3389/fnana.2017.00060

Abstract

Central noradrenergic neurons, collectively defined by synthesis of the neurotransmitter norepinephrine, are a diverse collection of cells in the hindbrain, differing in their anatomy, physiological and behavioral functions, and susceptibility to disease and environmental insult. To investigate the developmental basis of this heterogeneity, we have used an intersectional genetic fate mapping strategy in mice to study the dorsoventral origins of the

Keywords: Dbh; En1; Pax7; intersectional fate mapping; locus coeruleus; norepinephrine; recombinases; rhombomeres

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