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Miyazaki H, Midorikawa N, Fujimoto S, et al. Antimicrobial effects of lysophosphatidylcholine on methicillin-resistant . Ther Adv Infect Dis. 2017;4(4):89-94doi: 10.1177/2049936117714920.
Miyazaki, H., Midorikawa, N., Fujimoto, S., Miyoshi, N., Yoshida, H., & Matsumoto, T. (2017). Antimicrobial effects of lysophosphatidylcholine on methicillin-resistant . Therapeutic advances in infectious disease, 4(4), 89-94. https://doi.org/10.1177/2049936117714920
Miyazaki, Haruko, et al. "Antimicrobial effects of lysophosphatidylcholine on methicillin-resistant ." Therapeutic advances in infectious disease vol. 4,4 (2017): 89-94. doi: https://doi.org/10.1177/2049936117714920
Miyazaki H, Midorikawa N, Fujimoto S, Miyoshi N, Yoshida H, Matsumoto T. Antimicrobial effects of lysophosphatidylcholine on methicillin-resistant . Ther Adv Infect Dis. 2017 Jul;4(4):89-94. doi: 10.1177/2049936117714920. Epub 2017 Jul 05. PMID: 28748087; PMCID: PMC5507393.
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Ther Adv Infect Dis. 2017 Jul;4(4):89-94. doi: 10.1177/2049936117714920. Epub 2017 Jul 05.

Antimicrobial effects of lysophosphatidylcholine on methicillin-resistant .

Therapeutic advances in infectious disease

Haruko Miyazaki, Naoko Midorikawa, Saki Fujimoto, Natsumi Miyoshi, Hideto Yoshida, Tetsuya Matsumoto

Affiliations

  1. Department of Microbiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan.
  2. Department of Microbiology, Tokyo Medical University, Tokyo, Japan.
  3. Department of Fine Chemicals, Institute of Product Development, Research & Development Division, Kewpie Corporation, Tokyo, Japan.

PMID: 28748087 PMCID: PMC5507393 DOI: 10.1177/2049936117714920

Abstract

OBJECTIVES: Methicillin-resistant

METHODS: The LPC minimum inhibitory concentrations (MIC) for Gram-positive (

RESULTS: The LPC MIC for Gram-positive bacteria varied between 32 µg/ml and >2048 µg/ml, whereas that for all Gram-negative bacteria was >2048 µg/ml. Consistently, membrane permeability analysis showed that LPC was substantially more effective in inducing membrane permeability in Gram-positive bacteria than in Gram-negative counterparts. Growth curve analysis in cotreatment studies demonstrated that LPC has intrinsic bactericidal effects and can also potentiate gentamicin sensitivity in resistant MRSA strains.

CONCLUSIONS: Our study demonstrates that LPC exhibits intrinsic antimicrobial effects and can enhance the antimicrobial effects of gentamicin for resistant MRSA strains, suggesting that LPC may be a beneficial additive in topical antibiotics for superficial skin infections.

Keywords: cell membrane permeability; combination treatment study; lysophosphatidylcholine; methicillin-resistant Staphylococcus aureus

Conflict of interest statement

Conflict of interest statement: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr. Matsumoto has bee

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