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Zhvania P, Hoyle NS, Nadareishvili L, et al. Phage Therapy in a 16-Year-Old Boy with Netherton Syndrome. Front Med (Lausanne). 2017;4:94doi: 10.3389/fmed.2017.00094.
Zhvania, P., Hoyle, N. S., Nadareishvili, L., Nizharadze, D., & Kutateladze, M. (2017). Phage Therapy in a 16-Year-Old Boy with Netherton Syndrome. Frontiers in medicine, 494. https://doi.org/10.3389/fmed.2017.00094
Zhvania, Pikria, et al. "Phage Therapy in a 16-Year-Old Boy with Netherton Syndrome." Frontiers in medicine vol. 4 (2017): 94. doi: https://doi.org/10.3389/fmed.2017.00094
Zhvania P, Hoyle NS, Nadareishvili L, Nizharadze D, Kutateladze M. Phage Therapy in a 16-Year-Old Boy with Netherton Syndrome. Front Med (Lausanne). 2017 Jul 03;4:94. doi: 10.3389/fmed.2017.00094. eCollection 2017. PMID: 28717637; PMCID: PMC5494523.
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Front Med (Lausanne). 2017 Jul 03;4:94. doi: 10.3389/fmed.2017.00094. eCollection 2017.

Phage Therapy in a 16-Year-Old Boy with Netherton Syndrome.

Frontiers in medicine

Pikria Zhvania, Naomi Sulinger Hoyle, Lia Nadareishvili, Dea Nizharadze, Mzia Kutateladze

Affiliations

  1. Eliava Phage Therapy Center, Tbilisi, Georgia.
  2. G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia.

PMID: 28717637 PMCID: PMC5494523 DOI: 10.3389/fmed.2017.00094

Abstract

Netherton syndrome (NS) is a rare autosomal recessive disorder, characterized by a classical triad of clinical features, including congenital ichthyosiform erythroderma, trichorrhexis invaginata, and atopic diathesis coupled with frequent bacterial infections (1). The genetic basis for the disease has been recently identified with mutations in gene SPINK5, which is involved in the regulation of formation of skin barriers. We report on a 16-year-old male with all the typical manifestations of NS, including atopic diathesis and ongoing serious staphylococcal infections and allergy to multiple antibiotics whose family sought help at the Eliava Phage Therapy Center when all other treatment options were failing. Treatment with several antistaphylococcal bacteriophage preparations led to significant improvement within 7 days and very substantial changes in his symptoms and quality of life after treatment for 6 months, including return visits to the Eliava Phage Therapy Center after 3 and 6 months of ongoing use of phage at home.

Keywords: Eliava; Netherton syndrome; antibiotic resistance; bacteriophages; pediatrics; phage therapy; staphylococcal infections

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