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Master S, Leary C, Takalkar A, et al. Successful Treatment of Richter Transformation with Ibrutinib in a Patient with Chronic Lymphocytic Leukemia following Allogeneic Hematopoietic Stem Cell Transplant. Case Rep Oncol. 2017;10(2):534-541doi: 10.1159/000477338.
Master, S., Leary, C., Takalkar, A., Coltelingam, J., Mansour, R., Mills, G. M., & Koshy, N. (2017). Successful Treatment of Richter Transformation with Ibrutinib in a Patient with Chronic Lymphocytic Leukemia following Allogeneic Hematopoietic Stem Cell Transplant. Case reports in oncology, 10(2), 534-541. https://doi.org/10.1159/000477338
Master, Samip, et al. "Successful Treatment of Richter Transformation with Ibrutinib in a Patient with Chronic Lymphocytic Leukemia following Allogeneic Hematopoietic Stem Cell Transplant." Case reports in oncology vol. 10,2 (2017): 534-541. doi: https://doi.org/10.1159/000477338
Master S, Leary C, Takalkar A, Coltelingam J, Mansour R, Mills GM, Koshy N. Successful Treatment of Richter Transformation with Ibrutinib in a Patient with Chronic Lymphocytic Leukemia following Allogeneic Hematopoietic Stem Cell Transplant. Case Rep Oncol. 2017 Jun 19;10(2):534-541. doi: 10.1159/000477338. eCollection 2017. PMID: 28690529; PMCID: PMC5498945.
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Case Rep Oncol. 2017 Jun 19;10(2):534-541. doi: 10.1159/000477338. eCollection 2017.

Successful Treatment of Richter Transformation with Ibrutinib in a Patient with Chronic Lymphocytic Leukemia following Allogeneic Hematopoietic Stem Cell Transplant.

Case reports in oncology

Samip Master, Cheri Leary, Amol Takalkar, James Coltelingam, Richard Mansour, Glenn M Mills, Nebu Koshy

Affiliations

  1. Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.

PMID: 28690529 PMCID: PMC5498945 DOI: 10.1159/000477338

Abstract

Patients with chronic lymphocytic leukemia (CLL) who progress to Richter transformation (RT) have a poor prognosis. Multi-agent chemotherapy regimens do not have good response rates. There are few case reports on the use of ibrutinib in RT. Here, we present a patient who was heavily pretreated for CLL, including allogeneic stem cell transplant, and progressed to RT. She had a mixed response to multi-agent chemotherapy and was started on ibrutinib. She had a complete response for 16 months on single-agent ibrutinib with minimal toxicity.

Keywords: Chronic lymphocytic leukemia; Ibrutinib; Ibrutinib after allogeneic transplant; Richter transformation

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