Display options
Cite
Massart J, Begriche K, Moreau C, et al. Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity. J Clin Transl Res. 2017;3:212-232doi: 10.18053/jctres.03.2017S1.006.
Massart, J., Begriche, K., Moreau, C., & Fromenty, B. (2017). Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity. Journal of clinical and translational research, 3212-232. https://doi.org/10.18053/jctres.03.2017S1.006
Massart, Julie, et al. "Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity." Journal of clinical and translational research vol. 3 (2017): 212-232. doi: https://doi.org/10.18053/jctres.03.2017S1.006
Massart J, Begriche K, Moreau C, Fromenty B. Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity. J Clin Transl Res. 2017 Feb;3:212-232. doi: 10.18053/jctres.03.2017S1.006. Epub 2017 Feb 12. PMID: 28691103; PMCID: PMC5500243.
Copy Download .nbib Format: NLM
Share it on

J Clin Transl Res. 2017 Feb;3:212-232. doi: 10.18053/jctres.03.2017S1.006. Epub 2017 Feb 12.

Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity.

Journal of clinical and translational research

Julie Massart, Karima Begriche, Caroline Moreau, Bernard Fromenty

Affiliations

  1. Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden.
  2. INSERM, U991, Université de Rennes 1, Rennes, France.
  3. Service de Biochimie et Toxicologie, CHU Pontchaillou, Rennes, France.

PMID: 28691103 PMCID: PMC5500243 DOI: 10.18053/jctres.03.2017S1.006

Abstract

BACKGROUND: Obesity is often associated with nonalcoholic fatty liver disease (NAFLD), which refers to a large spectrum of hepatic lesions including fatty liver, nonalcoholic steatohepatitis (NASH) and cirrhosis. Different investigations showed or suggested that obesity and NAFLD are able to increase the risk of hepatotoxicity of different drugs. Some of these drugs could induce more frequently an acute hepatitis in obese individuals whereas others could worsen pre-existing NAFLD.

AIM: The main objective of the present review was to collect the available information regarding the role of NAFLD as risk factor for drug-induced hepatotoxicity. For this purpose, we performed a data-mining analysis using different queries including drug-induced liver injury (or DILI), drug-induced hepatotoxicity, fatty liver, nonalcoholic fatty liver disease (or NAFLD), steatosis and obesity. The main data from the collected articles are reported in this review and when available, some pathophysiological hypotheses are put forward.

RELEVANCE FOR PATIENTS: Drugs that could pose a potential risk in obese patients include compounds belonging to different pharmacological classes such as acetaminophen, halothane, methotrexate, rosiglitazone, stavudine and tamoxifen. For some of these drugs, experimental investigations in obese rodents confirmed the clinical observations and unveiled different pathophysiological mechanisms which could explain why these pharmaceuticals are particularly hepatotoxic in obesity and NAFLD. Other drugs such as pentoxifylline, phenobarbital and omeprazole might also pose a risk but more investigations are required to determine whether this risk is significant or not. Because obese people often take several drugs for the treatment of different obesity-related diseases such as type 2 diabetes, hyperlipidemia and coronary heart disease, it is urgent to identify the main pharmaceuticals that can cause acute hepatitis on a fatty liver background or induce NAFLD worsening.

Keywords: DILI; NAFLD; acetaminophen; cytochrome P450; drug; halothane; hepatotoxicity; isoflurane; liver; methotrexate; mitochondria; obesity; pentoxifylline; rosiglitazone; stavudine; tamoxifen; toxicity

References

  1. Intern Med. 2007;46(9):579-81 - PubMed
  2. J Hepatol. 2004 Oct;41(4):592-8 - PubMed
  3. Biochem Pharmacol. 1991 Feb 15;41(4):638-41 - PubMed
  4. J Biol Chem. 2005 Mar 18;280(11):9887-94 - PubMed
  5. Circulation. 2010 Nov 2;122(18):1789-96 - PubMed
  6. Dis Model Mech. 2015 Feb;8(2):183-91 - PubMed
  7. Hepatology. 2007 Jan;45(1):72-9 - PubMed
  8. FEBS Lett. 2005 Nov 21;579(28):6423-7 - PubMed
  9. Clin Res Hepatol Gastroenterol. 2011 Oct;35(10):630-7 - PubMed
  10. Rheum Dis Clin North Am. 1997 Nov;23 (4):883-915 - PubMed
  11. Toxicology. 2015 Dec 2;338:47-58 - PubMed
  12. Am J Gastroenterol. 2000 Jan;95(1):272-6 - PubMed
  13. Eur J Drug Metab Pharmacokinet. 1998 Oct-Dec;23(4):443-51 - PubMed
  14. Gastroenterol Clin Biol. 2004 Aug-Sep;28(8-9):720-59 - PubMed
  15. Liver Int. 2015 Nov;35(11):2343-53 - PubMed
  16. In Vivo. 1993 Nov-Dec;7(6A):497-501 - PubMed
  17. PLoS One. 2013 May 28;8(5):e63623 - PubMed
  18. Gastroenterology. 2004 May;126(5):1287-92 - PubMed
  19. BMJ. 2010 Dec 02;341:c6764 - PubMed
  20. Am J Physiol Endocrinol Metab. 2012 Mar 1;302(5):E532-9 - PubMed
  21. World J Gastroenterol. 2014 Jan 14;20(2):569-77 - PubMed
  22. Nature. 2000 Oct 19;407(6806):920-3 - PubMed
  23. J Rheumatol. 2004 Sep;31(9):1727-31 - PubMed
  24. J Clin Pathol. 2009 Jun;62(6):481-92 - PubMed
  25. Annu Rev Pathol. 2016 May 23;11:451-96 - PubMed
  26. Toxicol Sci. 2016 Mar;150(1):204-15 - PubMed
  27. Mol Cell Endocrinol. 2013 Oct 15;379(1-2):35-42 - PubMed
  28. Toxicol Appl Pharmacol. 2015 Apr 15;284(2):134-41 - PubMed
  29. Toxicology. 2006 Mar 15;220(2-3):169-78 - PubMed
  30. Toxicol Appl Pharmacol. 2001 Nov 1;176(3):145-52 - PubMed
  31. Obesity (Silver Spring). 2013 Sep;21(9):E415-20 - PubMed
  32. Toxicol Appl Pharmacol. 2016 Jan 1;290:86-97 - PubMed
  33. AIDS Res Hum Retroviruses. 2012 Aug;28(8):759-65 - PubMed
  34. Antivir Ther. 2007;12 (3):389-400 - PubMed
  35. Nat Genet. 2005 Aug;37(8):835-43 - PubMed
  36. Clin Pharmacol Ther. 2011 Jun;89(6):806-15 - PubMed
  37. J Endocrinol. 2014 Dec;223(3):R49-62 - PubMed
  38. Hepatology. 2009 Dec;50(6):1809-17 - PubMed
  39. N Engl J Med. 2015 Apr 23;372(17):1619-28 - PubMed
  40. Gastroenterology. 2014 Jul;147(1):109-118.e5 - PubMed
  41. Hepatology. 2009 Feb;49(2):436-42 - PubMed
  42. Anesthesiology. 1982 Aug;57(2):94-7 - PubMed
  43. Arthritis Care Res (Hoboken). 2014 Aug;66(8):1159-66 - PubMed
  44. Aliment Pharmacol Ther. 2007 Dec;26(11-12):1543-4; author reply 1545-6 - PubMed
  45. Ann Intern Med. 2000 Jan 18;132(2):121-4 - PubMed
  46. Hepatology. 2015 Apr;61(4):1124-6 - PubMed
  47. Hepatology. 1991 Jun;13(6):1017-21 - PubMed
  48. Anesth Analg. 1990 Jan;70(1):22-8 - PubMed
  49. Hepatology. 2010 Feb;51(2):445-53 - PubMed
  50. Clin Infect Dis. 2001 Dec 1;33(11):1914-21 - PubMed
  51. J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S74-80 - PubMed
  52. J Gastrointestin Liver Dis. 2009 Dec;18(4):419-23 - PubMed
  53. Br J Anaesth. 2009 Dec;103(6):899-900 - PubMed
  54. Hepatology. 2008 Oct;48(4):1336-41 - PubMed
  55. Toxicol Sci. 2012 Oct;129(2):332-45 - PubMed
  56. Toxicology. 2013 Oct 4;312:83-96 - PubMed
  57. Clin Infect Dis. 2007 Jul 15;45(2):254-60 - PubMed
  58. Alcohol Clin Exp Res. 2016 Jun;40(6):1295-303 - PubMed
  59. J Hepatol. 2011 Sep;55(3):673-82 - PubMed
  60. JAMA. 1999 Nov 3;282(17):1659-64 - PubMed
  61. Hepatol Res. 2007 Jun;37(6):410-5 - PubMed
  62. Drug Chem Toxicol. 2010 Apr;33(2):138-51 - PubMed
  63. AIDS Patient Care STDS. 2007 May;21(5):297-305 - PubMed
  64. Antimicrob Agents Chemother. 2006 Jun;50(6):2042-9 - PubMed
  65. Expert Opin Drug Metab Toxicol. 2015 ;11(11):1769-79 - PubMed
  66. Lancet. 1998 Mar 7;351(9104):725 - PubMed
  67. Toxicol Sci. 2007 Nov;100(1):259-66 - PubMed
  68. S Afr Med J. 2006 Aug;96(8):722-4 - PubMed
  69. Diabetes Care. 2008 Feb;31(2):221-2 - PubMed
  70. Anesthesiology. 1999 Mar;90(3):766-71 - PubMed
  71. Biochem Pharmacol. 2008 Mar 15;75(6):1402-10 - PubMed
  72. Toxicol Appl Pharmacol. 2016 Feb 1;292:40-55 - PubMed
  73. Clin Sci (Lond). 1982 Mar;62(3):279-83 - PubMed
  74. Toxicol Sci. 2012 Oct;129(2):346-62 - PubMed
  75. AJR Am J Roentgenol. 2003 Jan;180(1):129-34 - PubMed
  76. J Hepatol. 2016 Aug;65(2):399-412 - PubMed
  77. Immunol Res. 2014 Dec;60(2-3):289-310 - PubMed
  78. Biochim Biophys Acta. 2011 Aug;1812(8):995-1006 - PubMed
  79. Biomed Res Int. 2014;2014:120179 - PubMed
  80. J Hepatol. 2011 Apr;54(4):773-94 - PubMed
  81. World J Gastroenterol. 2010 Oct 14;16(38):4784-91 - PubMed
  82. Pharmacol Res. 2012 Jan;65(1):120-8 - PubMed
  83. Br J Pharmacol. 2012 Mar;165(5):1361-74 - PubMed
  84. Toxicol Appl Pharmacol. 2007 Sep 15;223(3):277-87 - PubMed
  85. J Am Coll Surg. 2005 Jun;200(6):845-53 - PubMed
  86. Clin Gastroenterol Hepatol. 2006 Dec;4(12):1544-9 - PubMed
  87. Annu Rev Pharmacol Toxicol. 2001;41:443-70 - PubMed
  88. Hepatology. 2013 Oct;58(4):1497-507 - PubMed
  89. BMJ. 2010 Mar 11;340:c1240 - PubMed
  90. Nutrition. 2009 Feb;25(2):200-8 - PubMed
  91. Pharmacol Res Perspect. 2016 Feb 04;4(1):e00211 - PubMed
  92. Free Radic Biol Med. 2013 Dec;65:952-68 - PubMed
  93. Am J Physiol. 1997 May;272(5 Pt 1):G1141-50 - PubMed
  94. Toxicol Pathol. 2014 Jul;42(5):811-22 - PubMed
  95. Curr Hepatol Rep. 2014 Jun 1;13(2):119-129 - PubMed
  96. Am J Gastroenterol. 2004 Dec;99(12):2365-8 - PubMed
  97. J Hepatol. 2013 Apr;58(4):824-6 - PubMed
  98. Crit Rev Toxicol. 2014 Jan;44(1):64-82 - PubMed
  99. Drug Metab Dispos. 1993 Sep-Oct;21(5):782-7 - PubMed
  100. Ann Hepatol. 2011 Jul-Sep;10(3):277-86 - PubMed
  101. J Pharmacol Exp Ther. 1987 Nov;243(2):565-70 - PubMed
  102. Hepatology. 2007 Aug;46(2):414-23 - PubMed
  103. Toxicol Sci. 2014 Nov;142(1):45-55 - PubMed
  104. Anesthesiology. 1975 Apr;42(4):451-7 - PubMed
  105. Health Aff (Millwood). 2009 Sep-Oct;28(5):w822-31 - PubMed
  106. Hepatology. 1988 Sep-Oct;8(5):1056-62 - PubMed
  107. Liver Int. 2013 Nov;33(10 ):1583-93 - PubMed
  108. Redox Biol. 2015;4:375-80 - PubMed
  109. J Lipid Res. 2002 Nov;43(11):1809-17 - PubMed
  110. Drug Metab Pharmacokinet. 2011;26(1):60-70 - PubMed
  111. Liver Int. 2014 Aug;34(7):e171-9 - PubMed
  112. Clin J Am Soc Nephrol. 2014 Jan;9(1):191-200 - PubMed
  113. Mitochondrion. 2006 Feb;6(1):1-28 - PubMed
  114. Am J Physiol Gastrointest Liver Physiol. 2012 Apr 15;302(8):G850-63 - PubMed
  115. J Diabetes Investig. 2013 Nov 27;4(6):517-24 - PubMed
  116. J Caffeine Res. 2012 May 24;2(1):45-47 - PubMed
  117. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 1;304(1):G38-47 - PubMed
  118. BMJ. 2005 Apr 23;330(7497):932 - PubMed
  119. Hepatol Res. 2014 Nov;44(12):1241-1247 - PubMed
  120. J Hepatol. 2010 Dec;53(6):1035-40 - PubMed
  121. Liver Int. 2006 Mar;26(2):151-6 - PubMed
  122. J Gastroenterol Hepatol. 2007 May;22(5):634-8 - PubMed
  123. Br J Dermatol. 1980 Apr;102(4):407-12 - PubMed
  124. Hepatology. 2010 Sep;52(3):1143-55 - PubMed
  125. Annu Rev Pharmacol Toxicol. 1999;39:1-17 - PubMed
  126. Handb Exp Pharmacol. 2010;(196 ):419-35 - PubMed
  127. Diabetes. 2005 Jun;54(6):1854-62 - PubMed
  128. Cancer. 2009 Jul 15;115(14):3189-95 - PubMed
  129. Int J Physiol Pathophysiol Pharmacol. 2016 Apr 25;8(1):14-27 - PubMed
  130. Biomed Res Int. 2015 ;2015 :168905 - PubMed
  131. Hepatology. 2010 Dec;52(6):2065-76 - PubMed
  132. Hepatology. 2016 Feb;63(2):590-603 - PubMed
  133. J Hepatol. 2012 Oct;57(4):860-6 - PubMed
  134. Toxicol Lett. 1999 Jun 1;106(2-3):171-80 - PubMed
  135. Cell Biol Toxicol. 2000;16(4):207-19 - PubMed
  136. Eur J Gastroenterol Hepatol. 2009 Sep;21(9):973-83 - PubMed
  137. JAMA. 2006 Jul 5;296(1):87-93 - PubMed
  138. J Cell Biochem. 2015 Sep;116(9):1939-46 - PubMed
  139. J Proteome Res. 2014 Mar 7;13(3):1731-43 - PubMed
  140. J Gastroenterol Hepatol. 2001 Dec;16(12):1395-401 - PubMed
  141. Clin Pharmacol Ther. 2010 Jul;88(1):45-51 - PubMed
  142. Anesthesiology. 1995 Dec;83(6):1361-4 - PubMed
  143. J Hepatol. 2007 Jun;46(6):1111-8 - PubMed
  144. Hepatology. 2002 Aug;36(2):451-5 - PubMed
  145. Eur J Clin Pharmacol. 2014 Oct;70(10):1159-72 - PubMed
  146. Intern Med. 2014;53(14):1531-4 - PubMed
  147. Toxicol Appl Pharmacol. 2014 Mar 15;275(3):189-97 - PubMed
  148. J Clin Oncol. 2006 May 1;24(13):2065-72 - PubMed
  149. World J Gastroenterol. 2008 Sep 14;14 (34):5322-6 - PubMed
  150. Hepat Mon. 2015 Nov 28;15(11):e32418 - PubMed
  151. Am J Ther. 2016 May-Jun;23 (3):e714-9 - PubMed
  152. Acta Anaesthesiol Scand. 1976;20(1):40-6 - PubMed
  153. Br J Dermatol. 2009 Mar;160(3):622-8 - PubMed
  154. Eur J Gastroenterol Hepatol. 2004 Jun;16(6):593-8 - PubMed
  155. J Ultrasound Med. 2015 Sep;34(9):1621-30 - PubMed
  156. Hepatology. 2003 Oct;38(4):1008-17 - PubMed
  157. Am J Med. 1991 Jun;90(6):711-6 - PubMed
  158. Drug Metab Dispos. 2015 Oct;43(10):1484-90 - PubMed
  159. Hepatology. 2009 Apr;49(4):1399-400 - PubMed
  160. Ann Intern Med. 2000 Jan 18;132(2):118-21 - PubMed
  161. Fundam Clin Pharmacol. 1998;12(5):553-8 - PubMed
  162. Biochim Biophys Acta. 2016 May;1861(5):471-81 - PubMed
  163. Hepatology. 2003 Jul;38(1):244-51 - PubMed
  164. Gastroenterology. 2015 Jun;148(7):1340-52.e7 - PubMed
  165. Exp Mol Pathol. 2014 Dec;97(3):492-510 - PubMed
  166. Clin Liver Dis. 2012 Aug;16(3):525-48 - PubMed
  167. Biochem Pharmacol. 2008 Jul 15;76(2):216-24 - PubMed
  168. Antivir Ther. 2004 Apr;9(2):161-77 - PubMed
  169. Proteomics. 2015 Jan;15(1):148-59 - PubMed
  170. Gastroenterology. 2008 Dec;135(6):1924-34, 1934.e1-4 - PubMed
  171. J Physiol Pharmacol. 2014 Oct;65(5):623-31 - PubMed
  172. J Hepatol. 2007 Oct;47(4):521-6 - PubMed
  173. Sci Rep. 2015 Mar 20;5:9284 - PubMed
  174. J Acquir Immune Defic Syndr. 2008 Dec 1;49(4):369-76 - PubMed
  175. Cell Metab. 2014 Oct 7;20(4):573-91 - PubMed
  176. J Agric Food Chem. 2013 Jun 26;61(25):6069-76 - PubMed
  177. Toxicol In Vitro. 2013 Mar;27(2):560-9 - PubMed
  178. Clin Pharmacol Ther. 1994 Oct;56(4):359-67 - PubMed
  179. Clin Pharmacokinet. 2012 May 1;51(5):277-304 - PubMed
  180. Clin Infect Dis. 2008 Jul 15;47(2):250-7 - PubMed
  181. J Hepatol. 1995 Jul;23 (1):95-7 - PubMed
  182. J Eur Acad Dermatol Venereol. 2011 May;25 Suppl 2:12-8 - PubMed
  183. Biochim Biophys Acta. 2014 Jul;1842(7):959-70 - PubMed
  184. Toxicology. 2009 Jul 10;261(3):112-8 - PubMed
  185. J Pharmacol Exp Ther. 2007 May;321(2):526-35 - PubMed
  186. Hepatology. 1998 Jan;27(1):128-33 - PubMed
  187. Oncotarget. 2015 Jul 10;6(19):17031-8 - PubMed
  188. Toxicol In Vitro. 2008 Jun;22(4):887-98 - PubMed
  189. Fundam Clin Pharmacol. 2008 Aug;22(4):335-53 - PubMed
  190. Curr Opin Infect Dis. 2012 Feb;25(1):10-6 - PubMed
  191. Q J Med. 1975 Jan;44(173):99-114 - PubMed
  192. FEBS J. 2011 Nov;278(22):4252-60 - PubMed
  193. Toxicol In Vitro. 2007 Mar;21(2):271-6 - PubMed
  194. Ann Intern Med. 1995 Aug 1;123(3):236 - PubMed
  195. Hepatology. 2003 Aug;38(2):428-35 - PubMed
  196. Cell Signal. 2015 Sep;27(9):1831-9 - PubMed
  197. J Hepatol. 2004 Nov;41(5):751-7 - PubMed
  198. Clin Pharmacokinet. 2016 Jul;55(7):833-47 - PubMed
  199. Toxicol Sci. 2014 Nov;142(1):105-16 - PubMed
  200. Hepatology. 1997 Jan;25(1):108-11 - PubMed
  201. J Acquir Immune Defic Syndr. 2007 Nov 1;46(3):318-22 - PubMed
  202. Hepatology. 2003 Jul;38(1):133-40 - PubMed
  203. Basic Clin Pharmacol Toxicol. 2008 Apr;102(4):382-7 - PubMed
  204. J Hepatol. 2010 Dec;53(6):1108-16 - PubMed
  205. J Biol Chem. 2014 Oct 17;289(42):29406-19 - PubMed
  206. Lab Invest. 2013 Dec;93(12):1295-312 - PubMed
  207. Toxicology. 2006 Oct 3;227(1-2):53-61 - PubMed
  208. Exp Physiol. 2009 Feb;94(2):228-39 - PubMed
  209. Adv Pharmacol. 2015;74:303-72 - PubMed
  210. Semin Liver Dis. 2015 Aug;35(3):270-90 - PubMed
  211. Toxicol Sci. 2007 Jun;97(2):582-94 - PubMed
  212. Free Radic Biol Med. 2016 Feb;91:188-202 - PubMed
  213. Breast. 2016 Aug;28:67-72 - PubMed
  214. Gastroenterology. 2015 Mar;148(3):517-532.e3 - PubMed
  215. Biochem Biophys Res Commun. 2012 Feb 17;418(3):445-50 - PubMed
  216. Int J STD AIDS. 2000 Sep;11(9):611-6 - PubMed
  217. Toxicol Lett. 1992 Dec;64-65 Spec No:757-61 - PubMed
  218. Fundam Appl Toxicol. 1997 Dec;40(2):256-63 - PubMed
  219. Chem Biol Interact. 2014 Oct 5;222:18-26 - PubMed
  220. AIDS. 2012 Oct 23;26(16):1995-2006 - PubMed
  221. Biotechnol Bioeng. 2009 Apr 1;102(5):1466-74 - PubMed
  222. Pharmacol Ther. 1993;58(2):133-55 - PubMed
  223. J Gastroenterol Hepatol. 1997 Oct;12 (9-10):S242-50 - PubMed
  224. Biomed Pharmacother. 2008 Nov;62(9):567-72 - PubMed
  225. Can Med Assoc J. 1973 Jan 20;108(2):171-7 - PubMed
  226. Toxicology. 2006 Aug 15;225(2-3):109-18 - PubMed
  227. Hum Toxicol. 1988 Nov;7(6):561-2 - PubMed
  228. Br J Clin Pharmacol. 2003 Jan;55(1):77-85 - PubMed
  229. J Hepatol. 2003 Apr;38(4):434-40 - PubMed
  230. Pharmacogenomics. 2013 Jan;14 (1):63-73 - PubMed
  231. Biochem J. 2004 Sep 1;382(Pt 2):491-9 - PubMed
  232. Lancet. 1999 Jan 2;353(9146):36-7 - PubMed
  233. J Pharmacol Exp Ther. 2012 Sep;342(3):676-87 - PubMed
  234. Am J Pathol. 2013 Apr;182(4):1180-7 - PubMed
  235. World J Hepatol. 2013 May 27;5(5):275-80 - PubMed
  236. Hepatology. 2010 Aug;52(2):774-88 - PubMed
  237. Can J Gastroenterol. 1996 Oct;10(6):369-75 - PubMed
  238. Hepatology. 2003 Mar;37(3):544-50 - PubMed
  239. Cell Biochem Funct. 1989 Apr;7(2):129-34 - PubMed
  240. Cell Rep. 2015 Mar 10;:null - PubMed
  241. AAPS J. 2016 Jul;18(4):1023-31 - PubMed
  242. J Cell Biol. 1968 Apr;37(1):63-79 - PubMed
  243. Drug Metab Dispos. 2003 Apr;31(4):421-31 - PubMed
  244. J Clin Invest. 2015 Dec;125(12):4447-62 - PubMed
  245. Hepatol Res. 2006 Feb;34(2):92-8 - PubMed
  246. Hepatology. 1986 Sep-Oct;6(5):814-22 - PubMed
  247. Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):676-85 - PubMed
  248. Pediatrics. 2011 Feb;127(2):e494-7 - PubMed
  249. Toxicol Appl Pharmacol. 2015 Nov 15;289(1):40-7 - PubMed
  250. J Lipid Res. 2016 Oct;57(10 ):1758-1770 - PubMed
  251. J Clin Lipidol. 2014 May-Jun;8(3 Suppl):S47-57 - PubMed
  252. Life Sci. 2015 Oct 15;139:132-8 - PubMed
  253. Redox Biol. 2016 Aug;8:216-25 - PubMed
  254. Antivir Ther. 2003 Oct;8(5):463-70 - PubMed
  255. Inflamm Res. 1998 Apr;47(4):148-51 - PubMed
  256. Hepatology. 2011 Jun;53(6):1895-905 - PubMed
  257. Am J Pathol. 2009 Nov;175(5):1929-37 - PubMed

Publication Types

Grant support