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Papierska L. Adrenopause - does it really exist?. Prz Menopauzalny. 2017;16(2):57-60doi: 10.5114/pm.2017.68593.
Papierska, L. (2017). Adrenopause - does it really exist?. Przeglad menopauzalny = Menopause review, 16(2), 57-60. https://doi.org/10.5114/pm.2017.68593
Papierska, Lucyna. "Adrenopause - does it really exist?." Przeglad menopauzalny = Menopause review vol. 16,2 (2017): 57-60. doi: https://doi.org/10.5114/pm.2017.68593
Papierska L. Adrenopause - does it really exist?. Prz Menopauzalny. 2017 Jun;16(2):57-60. doi: 10.5114/pm.2017.68593. Epub 2017 Jun 30. PMID: 28721131; PMCID: PMC5509973.
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Prz Menopauzalny. 2017 Jun;16(2):57-60. doi: 10.5114/pm.2017.68593. Epub 2017 Jun 30.

Adrenopause - does it really exist?.

Przeglad menopauzalny = Menopause review

Lucyna Papierska

Affiliations

  1. Department of Endocrinology, Centre of Postgraduate Medical Education, Biela?ski Hospital, Warsaw, Poland.

PMID: 28721131 PMCID: PMC5509973 DOI: 10.5114/pm.2017.68593

Abstract

In ageing human adrenal glands there occur some morphological changes which result in alterations of their cortex endocrine function. Glucocorticoid-excreting cells in the zona glomerulosa live longer than androgen-producing cells in the zona reticularis, which undergo significant apoptosis. Therefore, in elderly humans cortisol levels are normal (significantly higher than at young age), while adrenal androgen concentrations decline with ageing. Function of the zona glomerulosa is affected by the adrenal status, circulatory system condition, efficiency of the kidneys and liver and medication. An important problem of ageing is the rising incidence of non-secreting, incidentally detected, benign adrenal tumors, called incidentalomas. They necessitate clear-sighted radiological and hormonal diagnosis.

Keywords: DHEA; adrenal cortex; adrenal incidentaloma; adrenopause; glucocorticoids

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