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Seghal Kiran G, Priyadharshini S, Dobson ADW, et al. Degradation intermediates of polyhydroxy butyrate inhibits phenotypic expression of virulence factors and biofilm formation in luminescent . NPJ Biofilms Microbiomes. 2016;2:16002doi: 10.1038/npjbiofilms.2016.2.
Seghal Kiran, G., Priyadharshini, S., Dobson, A. D. W., Gnanamani, E., & Selvin, J. (2016). Degradation intermediates of polyhydroxy butyrate inhibits phenotypic expression of virulence factors and biofilm formation in luminescent . NPJ biofilms and microbiomes, 216002. https://doi.org/10.1038/npjbiofilms.2016.2
Seghal Kiran, George, et al. "Degradation intermediates of polyhydroxy butyrate inhibits phenotypic expression of virulence factors and biofilm formation in luminescent ." NPJ biofilms and microbiomes vol. 2 (2016): 16002. doi: https://doi.org/10.1038/npjbiofilms.2016.2
Seghal Kiran G, Priyadharshini S, Dobson ADW, Gnanamani E, Selvin J. Degradation intermediates of polyhydroxy butyrate inhibits phenotypic expression of virulence factors and biofilm formation in luminescent . NPJ Biofilms Microbiomes. 2016 Jun 15;2:16002. doi: 10.1038/npjbiofilms.2016.2. eCollection 2016. PMID: 28721241; PMCID: PMC5515267.
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NPJ Biofilms Microbiomes. 2016 Jun 15;2:16002. doi: 10.1038/npjbiofilms.2016.2. eCollection 2016.

Degradation intermediates of polyhydroxy butyrate inhibits phenotypic expression of virulence factors and biofilm formation in luminescent .

NPJ biofilms and microbiomes

George Seghal Kiran, Sethu Priyadharshini, Alan D W Dobson, Elumalai Gnanamani, Joseph Selvin

Affiliations

  1. Department of Food Science and Technology, Pondicherry University, Puducherry, India.
  2. School of Microbiology, University College Cork, Cork, Ireland.
  3. Environmental Research Institute, University College Cork, Cork, Ireland.
  4. Department of Chemistry, Stanford University, Stanford, CA, USA.
  5. Department of Microbiology, School of Life Sciences, Pondicherry University, Puducherry, India.

PMID: 28721241 PMCID: PMC5515267 DOI: 10.1038/npjbiofilms.2016.2

Abstract

Luminescent vibrios are ubiquitous in the marine environment and are the causative agents of vibriosis and mass mortality in many aquatic animals. In aquatic environments, treatments cannot be limited to the diseased population alone, therefore treatment of the entire aquatic system is the only possible approach. Thus, the use of antibiotics to treat part of the infected animals requires a dose based on the entire biomass, which results in the treatment of uninfected animals as well as non-target normal microbial flora. A treatment method based on anti-virulence or quorum quenching has recently been proposed as an effective treatment strategy for aquatic animals. Polyhydroxy butyrates (PHB) are bacterial storage molecules, which accumulate in cells under nutritional stress. The degradation of PHB releases short-chain β-hydroxy butyric acid, which may act as anti-infective molecule. To date, there is very limited information on the potential anti-infective and anti-virulence mechanisms involving PHB. In this study, we aim to examine the effect of PHB on inhibition of the virulence cascade of

Conflict of interest statement

The authors declare no conflict of interest.

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