Display options
Cite
Talboom JS, Velazquez R, Oddo S. The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease. NPJ Aging Mech Dis. 2015;1:15008doi: 10.1038/npjamd.2015.8.
Talboom, J. S., Velazquez, R., & Oddo, S. (2015). The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease. NPJ aging and mechanisms of disease, 115008. https://doi.org/10.1038/npjamd.2015.8
Talboom, Joshua S, et al. "The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease." NPJ aging and mechanisms of disease vol. 1 (2015): 15008. doi: https://doi.org/10.1038/npjamd.2015.8
Talboom JS, Velazquez R, Oddo S. The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease. NPJ Aging Mech Dis. 2015 Oct 15;1:15008. doi: 10.1038/npjamd.2015.8. eCollection 2015. PMID: 28721257; PMCID: PMC5514987.
Copy Download .nbib Format: NLM
Share it on

NPJ Aging Mech Dis. 2015 Oct 15;1:15008. doi: 10.1038/npjamd.2015.8. eCollection 2015.

The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease.

NPJ aging and mechanisms of disease

Joshua S Talboom, Ramon Velazquez, Salvatore Oddo

Affiliations

  1. Banner Sun Health Research Institute, Sun City, AZ, USA.
  2. Department of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, AZ, USA.

PMID: 28721257 PMCID: PMC5514987 DOI: 10.1038/npjamd.2015.8

Abstract

Age-dependent cognitive decline is a major debilitating event affecting even individuals who are otherwise healthy. Understanding the molecular basis underlying these changes may increase the healthspan of the elderly population. It may also reveal insights into the pathogenesis of numerous neurodegenerative disorders characterized by cognitive deficits, as aging is the major risk factor for most of these disorders. Alzheimer's disease (AD), the most common neurodegenerative disorder, first manifests itself as deficits in encoding new memories. As AD progresses, these deficits spread to other cognitive domains that further debilitate the person before contributing to their demise. Suppression of the mammalian target of rapamycin (mTOR) increases healthspan and lifespan in several organisms. Numerous reports have linked alterations in mTOR signaling to age-dependent cognitive decline and the pathogenesis of AD. This review will discuss recent work highlighting the complex role of mTOR in cognitive aging and in the pathogenesis of AD.

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. N Engl J Med. 2010 Jan 28;362(4):329-44 - PubMed
  2. Curr Biol. 2004 May 25;14(10):885-90 - PubMed
  3. Nat Neurosci. 2013 Nov;16(11):1537-43 - PubMed
  4. Annu Rev Genet. 2009;43:67-93 - PubMed
  5. Cell. 2011 Sep 2;146(5):682-95 - PubMed
  6. Cell Cycle. 2010 Feb 15;9(4):683-8 - PubMed
  7. Development. 2004 Aug;131(16):3897-906 - PubMed
  8. Mol Cells. 2015 May;38(5):381-9 - PubMed
  9. Genes Dev. 2004 Aug 15;18(16):1926-45 - PubMed
  10. Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72 - PubMed
  11. Nat Med. 2008 Aug;14(8):843-8 - PubMed
  12. Dev Cell. 2010 Jul 20;19(1):11-2 - PubMed
  13. Aging (Albany NY). 2013 Jun;5(6):474-84 - PubMed
  14. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7737-41 - PubMed
  15. J Neurochem. 2005 Apr;93(1):105-17 - PubMed
  16. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4913-7 - PubMed
  17. J Biol Chem. 2011 Mar 18;286(11):8924-32 - PubMed
  18. Science. 2014 Oct 31;346(6209):587-91 - PubMed
  19. Aging Cell. 2013 Jun;12 (3):370-80 - PubMed
  20. J Biol Chem. 1994 Jul 1;269(26):17386-9 - PubMed
  21. Physiol Rev. 2010 Oct;90(4):1383-435 - PubMed
  22. Pharmacol Res. 2014 Mar;81:54-63 - PubMed
  23. Neuroscience. 2012 Oct 25;223:102-13 - PubMed
  24. Trends Biochem Sci. 2006 Jun;31(6):342-8 - PubMed
  25. J Alzheimers Dis. 2015 ;44(4):1145-56 - PubMed
  26. Annu Rev Biophys. 2015;44:101-22 - PubMed
  27. Nat Rev Neurosci. 2011 Jul 20;12(8):437-52 - PubMed
  28. Nature. 2003 Dec 11;426(6967):620 - PubMed
  29. EMBO J. 2004 Feb 25;23(4):959-68 - PubMed
  30. Biochim Biophys Acta. 2015 Jul;1853(7):1646-57 - PubMed
  31. Mol Neurobiol. 2014 Feb;49(1):120-35 - PubMed
  32. Nature. 2013 Jan 17;493(7432):338-45 - PubMed
  33. J Biol Chem. 2009 Oct 2;284(40):27734-45 - PubMed
  34. Proc Natl Acad Sci U S A. 1986 Jun;83(11):4044-8 - PubMed
  35. Hum Mol Genet. 2011 Mar 15;20(6):1182-96 - PubMed
  36. Genes Dev. 1999 Jun 1;13(11):1422-37 - PubMed
  37. Amino Acids. 2015 Oct;47(10 ):2037-63 - PubMed
  38. Aging Cell. 2012 Apr;11(2):326-35 - PubMed
  39. Exp Gerontol. 2007 Aug;42(8):709-12 - PubMed
  40. J Clin Invest. 2015 Jan;125(1):25-32 - PubMed
  41. PLoS One. 2010 Sep 20;5(9):null - PubMed
  42. Nat Rev Neurosci. 2007 Sep;8(9):663-72 - PubMed
  43. Learn Mem. 2013 Sep 16;20(10):518-30 - PubMed
  44. PLoS One. 2011;6(9):e25416 - PubMed
  45. Curr Biol. 2006 Feb 7;16(3):230-41 - PubMed
  46. Physiology (Bethesda). 2006 Oct;21:362-9 - PubMed
  47. Biochem Soc Trans. 2012 Aug;40(4):644-52 - PubMed
  48. Prog Neurobiol. 2012 Feb;96(2):268-82 - PubMed
  49. FEBS Lett. 2008 Jan 23;582(2):159-64 - PubMed
  50. Aging (Albany NY). 2009 Jul 20;1(7):586-97 - PubMed
  51. J Neurosci. 2014 Jun 4;34(23):7988-98 - PubMed
  52. J Biol Chem. 2013 May 31;288(22):15556-70 - PubMed
  53. J Alzheimers Dis. 2013;37(3):483-94 - PubMed
  54. Nature. 2009 Jul 16;460(7253):392-5 - PubMed
  55. Nature. 1998 Jun 18;393(6686):702-5 - PubMed
  56. J Neurochem. 2005 Jul;94(1):215-25 - PubMed
  57. Neuron. 2015 Jan 21;85(2):303-15 - PubMed
  58. Cell. 2006 Feb 10;124(3):471-84 - PubMed
  59. Prog Neurobiol. 2013 Jun;105:49-59 - PubMed
  60. Neurobiol Dis. 2015 Dec;84:39-49 - PubMed
  61. Science. 2009 Oct 2;326(5949):140-4 - PubMed
  62. FEBS Lett. 2010 Apr 2;584(7):1287-95 - PubMed
  63. Exp Gerontol. 2015 Aug;68:51-8 - PubMed
  64. J Neurosci Res. 2012 Jun;90(6):1105-18 - PubMed
  65. Neuroreport. 2002 Dec 20;13(18):2429-32 - PubMed
  66. FEBS Lett. 2006 Jan 9;580(1):107-14 - PubMed
  67. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14368-73 - PubMed
  68. Nat Med. 2008 Sep;14(9):959-65 - PubMed
  69. Mol Biol Cell. 2007 Dec;18(12):5060-8 - PubMed
  70. Curr Biol. 2006 Sep 19;16(18):1865-70 - PubMed
  71. Adv Exp Med Biol. 2015;847:73-87 - PubMed
  72. Neurochem Int. 2015 Apr-May;83-84:9-18 - PubMed
  73. Science. 2001 Apr 13;292(5515):288-90 - PubMed
  74. J Neuropathol Exp Neurol. 2014 Jul;73(7):671-83 - PubMed
  75. Neurobiol Dis. 2011 Jul;43(1):38-45 - PubMed
  76. J Alzheimers Dis. 2008 Aug;14(4):385-92 - PubMed
  77. Nat Neurosci. 2013 Apr;16(4):441-8 - PubMed
  78. Front Biosci (Schol Ed). 2012 Jan 01;4:941-52 - PubMed
  79. Genes Dev. 2000 Nov 1;14(21):2689-94 - PubMed
  80. Science. 1999 Sep 24;285(5436):2126-9 - PubMed
  81. Tanpakushitsu Kakusan Koso. 2008 Dec;53(16 Suppl):2170-4 - PubMed
  82. J Clin Invest. 2013 Mar;123(3):980-9 - PubMed
  83. Proc Natl Acad Sci U S A. 1988 Jun;85(11):4051-5 - PubMed
  84. Cell Commun Signal. 2014 Mar 28;12:23 - PubMed
  85. J Biochem. 1986 Jun;99(6):1807-10 - PubMed
  86. J Neurosci. 2008 Jul 2;28(27):6926-37 - PubMed
  87. Cell Rep. 2013 Sep 12;4(5):913-20 - PubMed
  88. J Intellect Disabil Res. 2009 Oct;53(10):838-51 - PubMed
  89. J Cell Biol. 2005 Oct 10;171(1):87-98 - PubMed
  90. PLoS One. 2010 Apr 01;5(4):e9979 - PubMed
  91. Mol Cell Biol. 2004 Aug;24(15):6710-8 - PubMed
  92. J Neurochem. 2015 Jun;133(5):739-49 - PubMed
  93. Am J Pathol. 2003 Aug;163(2):591-607 - PubMed
  94. J Biol Chem. 2010 Apr 23;285(17):13107-20 - PubMed

Publication Types