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Murkey JA, Chew KW, Carlson M, et al. Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing. Open Forum Infect Dis. 2017;4(3):ofx121doi: 10.1093/ofid/ofx121.
Murkey, J. A., Chew, K. W., Carlson, M., Shannon, C. L., Sirohi, D., Sample, H. A., Wilson, M. R., Vespa, P., Humphries, R. M., Miller, S., Klausner, J. D., & Chiu, C. Y. (2017). Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing. Open forum infectious diseases, 4(3), ofx121. https://doi.org/10.1093/ofid/ofx121
Murkey, Jamie A, et al. "Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing." Open forum infectious diseases vol. 4,3 (2017): ofx121. doi: https://doi.org/10.1093/ofid/ofx121
Murkey JA, Chew KW, Carlson M, Shannon CL, Sirohi D, Sample HA, Wilson MR, Vespa P, Humphries RM, Miller S, Klausner JD, Chiu CY. Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing. Open Forum Infect Dis. 2017 Jun 13;4(3):ofx121. doi: 10.1093/ofid/ofx121. eCollection 2017. PMID: 28721353; PMCID: PMC5508774.
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Open Forum Infect Dis. 2017 Jun 13;4(3):ofx121. doi: 10.1093/ofid/ofx121. eCollection 2017.

Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.

Open forum infectious diseases

Jamie A Murkey, Kara W Chew, Margrit Carlson, Chelsea L Shannon, Deepika Sirohi, Hannah A Sample, Michael R Wilson, Paul Vespa, Romney M Humphries, Steve Miller, Jeffrey D Klausner, Charles Y Chiu

Affiliations

  1. Department of Medicine.
  2. Department of Laboratory Medicine.
  3. Department of Biochemistry and Biophysics.
  4. Weill Institute for Neurosciences, Department of Neurology.
  5. Department of Neurology, and.
  6. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California, Los Angeles; and.
  7. UCSF-Abbott Viral Diagnostics and Discovery Center and Department of Medicine, and.
  8. Department of Medicine, Division of Infectious Diseases, University of California, San Francisco.

PMID: 28721353 PMCID: PMC5508774 DOI: 10.1093/ofid/ofx121

Abstract

Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.

Keywords: encephalitis; hepatitis E virus; lung transplant; meningitis; metagenomic next-generation sequencing (mNGS).

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