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Rizwan A, Cheng M, Bhujwalla ZM, et al. Breast cancer cell adhesome and degradome interact to drive metastasis. NPJ Breast Cancer. 2015;1:15017doi: 10.1038/npjbcancer.2015.17.
Rizwan, A., Cheng, M., Bhujwalla, Z. M., Krishnamachary, B., Jiang, L., & Glunde, K. (2015). Breast cancer cell adhesome and degradome interact to drive metastasis. NPJ breast cancer, 115017. https://doi.org/10.1038/npjbcancer.2015.17
Rizwan, Asif, et al. "Breast cancer cell adhesome and degradome interact to drive metastasis." NPJ breast cancer vol. 1 (2015): 15017. doi: https://doi.org/10.1038/npjbcancer.2015.17
Rizwan A, Cheng M, Bhujwalla ZM, Krishnamachary B, Jiang L, Glunde K. Breast cancer cell adhesome and degradome interact to drive metastasis. NPJ Breast Cancer. 2015 Oct 28;1:15017. doi: 10.1038/npjbcancer.2015.17. eCollection 2015. PMID: 28721370; PMCID: PMC5515192.
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NPJ Breast Cancer. 2015 Oct 28;1:15017. doi: 10.1038/npjbcancer.2015.17. eCollection 2015.

Breast cancer cell adhesome and degradome interact to drive metastasis.

NPJ breast cancer

Asif Rizwan, Menglin Cheng, Zaver M Bhujwalla, Balaji Krishnamachary, Lu Jiang, Kristine Glunde

Affiliations

  1. The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  2. The Johns Hopkins University School of Medicine, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA.

PMID: 28721370 PMCID: PMC5515192 DOI: 10.1038/npjbcancer.2015.17

Abstract

BACKGROUND: Although primary breast tumors are detected early in most cases, it is inevitable that many patients remain at risk for future recurrence and death due to micrometastases. We investigated interactions between the degradome and the adhesome that drive metastasis, and have focused on matrix metalloproteases (MMPs) within the degradome and integrins and E-cadherin within the adhesome.

AIMS: The aim of this study is to identify interaction networks between adhesion molecules and degradative enzymes in breast cancer metastasis.

METHODS: We compared non-metastatic (BT-474, T47D, MCF7) and metastatic (MDA-MB-231, SUM149, SUM159) human breast cancer cell lines and xenografts, in which we measured growth rate, migration, invasion, colony formation, protein expression, and enzyme activity

RESULTS: The metastatic breast cancer lines and xenografts displayed higher expression and activity levels of MMPs, which was also confirmed by noninvasive imaging

CONCLUSIONS: Our results point toward a concerted interdependence of MMPs, ITGB1, and CDH1 that is critical for breast cancer metastasis.

Conflict of interest statement

The authors declare no conflict of interest.

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