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Lee CR, Wang B, Mojica JP, et al. Young inversion with multiple linked QTLs under selection in a hybrid zone. Nat Ecol Evol. 2017;1(5):119doi: 10.1038/s41559-017-0119.
Lee, C. R., Wang, B., Mojica, J. P., Mandáková, T., Prasad, K. V. S. K., Goicoechea, J. L., Perera, N., Hellsten, U., Hundley, H. N., Johnson, J., Grimwood, J., Barry, K., Fairclough, S., Jenkins, J. W., Yu, Y., Kudrna, D., Zhang, J., Talag, J., Golser, W., Ghattas, K., Schranz, M. E., Wing, R., Lysak, M. A., Schmutz, J., Rokhsar, D. S., & Mitchell-Olds, T. (2017). Young inversion with multiple linked QTLs under selection in a hybrid zone. Nature ecology & evolution, 1(5), 119. https://doi.org/10.1038/s41559-017-0119
Lee, Cheng-Ruei, et al. "Young inversion with multiple linked QTLs under selection in a hybrid zone." Nature ecology & evolution vol. 1,5 (2017): 119. doi: https://doi.org/10.1038/s41559-017-0119
Lee CR, Wang B, Mojica JP, Mandáková T, Prasad KVSK, Goicoechea JL, Perera N, Hellsten U, Hundley HN, Johnson J, Grimwood J, Barry K, Fairclough S, Jenkins JW, Yu Y, Kudrna D, Zhang J, Talag J, Golser W, Ghattas K, Schranz ME, Wing R, Lysak MA, Schmutz J, Rokhsar DS, Mitchell-Olds T. Young inversion with multiple linked QTLs under selection in a hybrid zone. Nat Ecol Evol. 2017 Apr 03;1(5):119. doi: 10.1038/s41559-017-0119. PMID: 28812690; PMCID: PMC5607633.
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Nat Ecol Evol. 2017 Apr 03;1(5):119. doi: 10.1038/s41559-017-0119.

Young inversion with multiple linked QTLs under selection in a hybrid zone.

Nature ecology & evolution

Cheng-Ruei Lee, Baosheng Wang, Julius P Mojica, Terezie Mandáková, Kasavajhala V S K Prasad, Jose Luis Goicoechea, Nadeesha Perera, Uffe Hellsten, Hope N Hundley, Jenifer Johnson, Jane Grimwood, Kerrie Barry, Stephen Fairclough, Jerry W Jenkins, Yeisoo Yu, Dave Kudrna, Jianwei Zhang, Jayson Talag, Wolfgang Golser, Kathryn Ghattas, M Eric Schranz, Rod Wing, Martin A Lysak, Jeremy Schmutz, Daniel S Rokhsar, Thomas Mitchell-Olds

Affiliations

  1. Department of Biology, Duke University, Box 90338, Durham, North Carolina 27708, USA.
  2. Institute of Ecology and Evolutionary Biology and Institute of Plant Biology, National Taiwan University, Taipei 10617, Taiwan ROC.
  3. Department of Plant Ecology and Genetics, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden.
  4. Plant Cytogenomics Group, Central European Institute of Technology, Masaryk University, Kamenice 5, Brno CZ-62500, Czech Republic.
  5. Department of Biology, Colorado State University, Fort Collins, Colorado 80523, USA.
  6. Arizona Genomics Institute and BIO5 Institute, School of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA.
  7. Department of Energy Joint Genome Institute, Walnut Creek, California 94598, USA.
  8. HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
  9. Phyzen Genomics Institute, Phyzen Inc., Seoul 151-836, South Korea.
  10. Biosystematics Group, Wageningen University and Research Center, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands.

PMID: 28812690 PMCID: PMC5607633 DOI: 10.1038/s41559-017-0119

Abstract

Fixed chromosomal inversions can reduce gene flow and promote speciation in two ways: by suppressing recombination and by carrying locally favoured alleles at multiple loci. However, it is unknown whether favoured mutations slowly accumulate on older inversions or if young inversions spread because they capture pre-existing adaptive quantitative trait loci (QTLs). By genetic mapping, chromosome painting and genome sequencing, we have identified a major inversion controlling ecologically important traits in Boechera stricta. The inversion arose since the last glaciation and subsequently reached local high frequency in a hybrid speciation zone. Furthermore, the inversion shows signs of positive directional selection. To test whether the inversion could have captured existing, linked QTLs, we crossed standard, collinear haplotypes from the hybrid zone and found multiple linked phenology QTLs within the inversion region. These findings provide the first direct evidence that linked, locally adapted QTLs may be captured by young inversions during incipient speciation.

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