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Zhao M, Liao D, Zhao J. Diabetes-induced mechanophysiological changes in the small intestine and colon. World J Diabetes. 2017;8(6):249-269doi: 10.4239/wjd.v8.i6.249.
Zhao, M., Liao, D., & Zhao, J. (2017). Diabetes-induced mechanophysiological changes in the small intestine and colon. World journal of diabetes, 8(6), 249-269. https://doi.org/10.4239/wjd.v8.i6.249
Zhao, Mirabella, et al. "Diabetes-induced mechanophysiological changes in the small intestine and colon." World journal of diabetes vol. 8,6 (2017): 249-269. doi: https://doi.org/10.4239/wjd.v8.i6.249
Zhao M, Liao D, Zhao J. Diabetes-induced mechanophysiological changes in the small intestine and colon. World J Diabetes. 2017 Jun 15;8(6):249-269. doi: 10.4239/wjd.v8.i6.249. PMID: 28694926; PMCID: PMC5483424.
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World J Diabetes. 2017 Jun 15;8(6):249-269. doi: 10.4239/wjd.v8.i6.249.

Diabetes-induced mechanophysiological changes in the small intestine and colon.

World journal of diabetes

Mirabella Zhao, Donghua Liao, Jingbo Zhao

Affiliations

  1. Mirabella Zhao, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

PMID: 28694926 PMCID: PMC5483424 DOI: 10.4239/wjd.v8.i6.249

Abstract

The disorders of gastrointestinal (GI) tract including intestine and colon are common in the patients with diabetes mellitus (DM). DM induced intestinal and colonic structural and biomechanical remodeling in animals and humans. The remodeling is closely related to motor-sensory abnormalities of the intestine and colon which are associated with the symptoms frequently encountered in patients with DM such as diarrhea and constipation. In this review, firstly we review DM-induced histomorphological and biomechanical remodeling of intestine and colon. Secondly we review motor-sensory dysfunction and how they relate to intestinal and colonic abnormalities. Finally the clinical consequences of DM-induced changes in the intestine and colon including diarrhea, constipation, gut microbiota change and colon cancer are discussed. The final goal is to increase the understanding of DM-induced changes in the gut and the subsequent clinical consequences in order to provide the clinicians with a better understanding of the GI disorders in diabetic patients and facilitates treatments tailored to these patients.

Keywords: Biomechanics; Colon; Diabetes; Gut microbiota; Intestine; Motor-sensory; Symptoms

Conflict of interest statement

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

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