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Parkinsons Dis. 2017;2017:2837685. doi: 10.1155/2017/2837685. Epub 2017 Jun 11.

Does Dopamine Depletion Trigger a Spreader Lexical-Semantic Activation in Parkinson's Disease? Evidence from a Study Based on Word Fluency Tasks.

Parkinson's disease

S Zabberoni, G A Carlesimo, A Peppe, C Caltagirone, A Costa

Affiliations

  1. Department of Psychology, Niccolò Cusano University, Rome, Italy.
  2. IRCCS Fondazione Santa Lucia, Rome, Italy.
  3. Department of Systems Medicine, Tor Vergata University, Rome, Italy.

PMID: 28695038 PMCID: PMC5485327 DOI: 10.1155/2017/2837685

Abstract

It has been hypothesised that, in Parkinson's disease (PD), dopamine might modulate spreading activation of lexical-semantic representations. We aimed to investigate this hypothesis in individuals with PD without dementia by assessing word frequency and typicality in verbal fluency tasks. We predicted that the average values of both of these parameters would be lower in PD patients with respect to healthy controls (HC). We administered letter-cued and category-cued fluency tasks to early PD patients in two experimental conditions: the tasks were administered both after 12-18 hours of dopaminergic stimulation withdrawal ("OFF" condition) and after the first daily dose of dopaminergic therapy ("ON" condition). HC were also given the two tasks in two conditions with the same intersession delay as PD patients but without taking drugs. Results showed that in both OFF and ON treatment conditions PD patients did not differ from HC in word frequency or typicality. Moreover, in the PD group, no significant difference was found between the experimental conditions. Our results show that semantic spreading was not altered in the PD sample examined; this suggests that in early PD the functioning of the semantic system is relatively independent from the activity of dopamine brain networks.

References

  1. Cortex. 2009 Sep;45(8):950-9 - PubMed
  2. Neurology. 1967 May;17(5):427-42 - PubMed
  3. J Int Neuropsychol Soc. 2004 Jan;10(1):15-25 - PubMed
  4. Cogn Behav Neurol. 2008 Sep;21(3):134-7 - PubMed
  5. Mov Disord. 2007 Dec;22(16):2314-24 - PubMed
  6. Brain. 2010 Nov;133(11):3423-33 - PubMed
  7. J Clin Exp Neuropsychol. 2007 Jan;29(1):73-85 - PubMed
  8. Neuropsychologia. 2009 Apr;47(5):1374-81 - PubMed
  9. J Clin Exp Neuropsychol. 2001 Aug;23(4):502-19 - PubMed
  10. Psychiatry Res. 2013 Jan 30;205(1-2):1-6 - PubMed
  11. J Neurol Neurosurg Psychiatry. 2004 Oct;75(10):1467-9 - PubMed
  12. Neurology. 2012 Jun 12;78(24):1939-45 - PubMed
  13. J Psychiatr Res. 1975 Nov;12(3):189-98 - PubMed
  14. Behav Neurol. 2014;2014:260896 - PubMed
  15. Neuropsychologia. 1996 Nov;34(11):1107-13 - PubMed
  16. Neuropsychologia. 2008;46(7):1908-14 - PubMed
  17. Eur Neurol. 1996;36(6):378-84 - PubMed
  18. Biol Psychiatry. 2006 Sep 15;60(6):604-11 - PubMed
  19. Neuropsychology. 2002 Apr;16(2):174-81 - PubMed
  20. Mov Disord. 1992;7(1):2-13 - PubMed
  21. Prog Neurobiol. 2009 Jun;88(2):89-103 - PubMed
  22. Lancet Neurol. 2010 Dec;9(12):1200-13 - PubMed
  23. Neuropsychology. 2006 May;20(3):299-306 - PubMed
  24. Neuropsychologia. 2012 Dec;50(14):3636-40 - PubMed
  25. Biol Psychiatry. 2011 Jun 15;69(12):e113-25 - PubMed
  26. Neurosci Biobehav Rev. 2006;30(1):1-23 - PubMed

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