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Wang Y, Gersten A, Moleirinho S, et al. Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression. Acad Pathol. 2015;2(4):2374289515616972doi: 10.1177/2374289515616972.
Wang, Y., Gersten, A., Moleirinho, S., Gunn-Moore, F. J., Reynolds, P. A., & Prystowsky, M. B. (2015). Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression. Academic pathology, 2(4), 2374289515616972. https://doi.org/10.1177/2374289515616972
Wang, Yanghua, et al. "Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression." Academic pathology vol. 2,4 (2015): 2374289515616972. doi: https://doi.org/10.1177/2374289515616972
Wang Y, Gersten A, Moleirinho S, Gunn-Moore FJ, Reynolds PA, Prystowsky MB. Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression. Acad Pathol. 2015 Nov 26;2(4):2374289515616972. doi: 10.1177/2374289515616972. eCollection 2015. PMID: 28725753; PMCID: PMC5479460.
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Acad Pathol. 2015 Nov 26;2(4):2374289515616972. doi: 10.1177/2374289515616972. eCollection 2015.

Fibroblasts in Head and Neck Squamous Cell Carcinoma Associated With Perineural Invasion Have High-Level Nuclear Yes-Associated Protein (YAP) Expression.

Academic pathology

Yanghua Wang, Adam Gersten, Susana Moleirinho, Frank J Gunn-Moore, Paul A Reynolds, Michael B Prystowsky

Affiliations

  1. Department of Pathology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.
  2. School of Biology, University of St Andrews, Scotland, United Kingdom.
  3. School of Medicine, University of St Andrews, Scotland, United Kingdom.

PMID: 28725753 PMCID: PMC5479460 DOI: 10.1177/2374289515616972

Abstract

We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma with associated perineural invasion. We find that fibroblasts in areas associated with perineural invasion show higher levels of nuclear YAP compared to fibroblasts in the stroma of normal mucosa, with a median cell count of 35.4 per high-power field in the former and 3.9 in the latter. No differences were observed between the expression of YAP phosphorylated at Ser127 in the tumoral stroma compared to that in the normal mucosa, with a median cell count expression of 4.9 in the former versus 5.0 in the latter. Therefore, a strong and increased nuclear YAP expression in fibroblasts associated with perineural invasion in head and neck squamous cell carcinoma suggests that YAP-mediated transcription programs in these fibroblasts may contribute to perineural invasion.

Keywords: YAP expression; fibroblast; perineural invasion; squamous cell carcinoma

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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