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Front Cell Neurosci. 2017 Jul 21;11:217. doi: 10.3389/fncel.2017.00217. eCollection 2017.

Differential .

Frontiers in cellular neuroscience

Yun-Fang Jia, YuBin Choi, Jennifer R Ayers-Ringler, Joanna M Biernacka, Jennifer R Geske, Daniel R Lindberg, Susan L McElroy, Mark A Frye, Doo-Sup Choi, Marin Veldic

Affiliations

  1. Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, RochesterMN, United States.
  2. Neurobiology of Disease Program, Mayo Graduate School, Mayo Clinic, RochesterMN, United States.
  3. Department of Psychiatry and Psychology, Mayo Clinic Depression Center, Mayo Clinic, RochesterMN, United States.
  4. Division of Biomedical Statistics and Informatics, Mayo Clinic, RochesterMN, United States.
  5. Lindner Center of HOPE, MasonOH, United States.
  6. Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, CincinnatiOH, United States.

PMID: 28785205 PMCID: PMC5520464 DOI: 10.3389/fncel.2017.00217

Abstract

While downregulation of excitatory amino acid transporter 2 (EAAT2), the main transporter removing glutamate from the synapse, has been recognized in bipolar disorder (BD), the underlying mechanisms of downregulation have not been elucidated. BD is influenced by environmental factors, which may, via epigenetic modulation of gene expression, differentially affect illness presentation. This study thus focused on epigenetic DNA methylation regulation of

Keywords: SLC1A2 (EAAT2); addiction; biomarkers; bipolar disorder; glutamate; methylation

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