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Mehboob R, Kabir M, Ahmed N, et al. Towards Better Understanding of the Pathogenesis of Neuronal Respiratory Network in Sudden Perinatal Death. Front Neurol. 2017;8:320doi: 10.3389/fneur.2017.00320.
Mehboob, R., Kabir, M., Ahmed, N., & Ahmad, F. J. (2017). Towards Better Understanding of the Pathogenesis of Neuronal Respiratory Network in Sudden Perinatal Death. Frontiers in neurology, 8320. https://doi.org/10.3389/fneur.2017.00320
Mehboob, Riffat, et al. "Towards Better Understanding of the Pathogenesis of Neuronal Respiratory Network in Sudden Perinatal Death." Frontiers in neurology vol. 8 (2017): 320. doi: https://doi.org/10.3389/fneur.2017.00320
Mehboob R, Kabir M, Ahmed N, Ahmad FJ. Towards Better Understanding of the Pathogenesis of Neuronal Respiratory Network in Sudden Perinatal Death. Front Neurol. 2017 Jul 06;8:320. doi: 10.3389/fneur.2017.00320. eCollection 2017. PMID: 28729852; PMCID: PMC5498558.
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Front Neurol. 2017 Jul 06;8:320. doi: 10.3389/fneur.2017.00320. eCollection 2017.

Towards Better Understanding of the Pathogenesis of Neuronal Respiratory Network in Sudden Perinatal Death.

Frontiers in neurology

Riffat Mehboob, Mahvish Kabir, Naseer Ahmed, Fridoon Jawad Ahmad

Affiliations

  1. Biomedical Sciences, King Edward Medical University, Lahore, Pakistan.
  2. Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.
  3. Department of Chemistry, School of Science, University of Management and Technology (UMT), Lahore, Pakistan.
  4. Department of Cardiac Surgery, University of Verona Medical School, Verona, Italy.
  5. Section of Pharmacology, University of Verona Medical School, Verona, Italy.

PMID: 28729852 PMCID: PMC5498558 DOI: 10.3389/fneur.2017.00320

Abstract

Sudden perinatal death that includes the victims of sudden infant death syndrome, sudden intrauterine death syndrome, and stillbirth are heartbreaking events in the life of parents. Most of the studies about sudden perinatal death were reported from Italy, highlighting two main etiological factors: prone sleeping position and smoking. Other probable contributory factors are prematurity, male gender, lack of breastfeeding, respiratory tract infections, use of pacifiers, infant botulism, extensive use of pesticides and insecticides, etc. However, extensive studies across the world are required to establish the role of these factors in a different subset of populations. Previous studies confirmed the widely accepted hypothesis that neuropathology of the brainstem is one of the main cause of sudden perinatal death. This study is an effort to summarize the neuropathological evaluation of the brainstems and their association to sudden perinatal death. Brainstem nuclei in vulnerable infants undergo certain changes that may alter the sleep arousal cycle, cardiorespiratory control, and ultimately culminate in death. This review focuses on the roles of different brainstem nuclei, their pathologies, and the established facts in this regard in terms of it's link to such deaths. This study will also help to understand the role of brainstem nuclei in controlling the cardiorespiratory cycles in sudden perinatal death and may provide a better understanding to resolve the mystery of these deaths in future. It is also found that a global initiative to deal with perinatal death is required to facilitate the diagnosis and prevention in developed and as well as developing countries.

Keywords: neuropathology; stillbirth; sudden fetal death; sudden infant death; sudden intrauterine death; sudden perinatal death

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