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Bonvin D, Alexander DTL, Millán A, et al. Tuning Properties of Iron Oxide Nanoparticles in Aqueous Synthesis without Ligands to Improve MRI Relaxivity and SAR. Nanomaterials (Basel). 2017;7(8)doi: 10.3390/nano7080225.
Bonvin, D., Alexander, D. T. L., Millán, A., Piñol, R., Sanz, B., Goya, G. F., Martínez, A., Bastiaansen, J. A. M., Stuber, M., Schenk, K. J., Hofmann, H., & Mionić Ebersold, M. (2017). Tuning Properties of Iron Oxide Nanoparticles in Aqueous Synthesis without Ligands to Improve MRI Relaxivity and SAR. Nanomaterials (Basel, Switzerland), 7(8), . https://doi.org/10.3390/nano7080225
Bonvin, Debora, et al. "Tuning Properties of Iron Oxide Nanoparticles in Aqueous Synthesis without Ligands to Improve MRI Relaxivity and SAR." Nanomaterials (Basel, Switzerland) vol. 7,8 (2017). doi: https://doi.org/10.3390/nano7080225
Bonvin D, Alexander DTL, Millán A, Piñol R, Sanz B, Goya GF, Martínez A, Bastiaansen JAM, Stuber M, Schenk KJ, Hofmann H, Mionić Ebersold M. Tuning Properties of Iron Oxide Nanoparticles in Aqueous Synthesis without Ligands to Improve MRI Relaxivity and SAR. Nanomaterials (Basel). 2017 Aug 18;7(8). doi: 10.3390/nano7080225. PMID: 28820442; PMCID: PMC5575707.
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Nanomaterials (Basel). 2017 Aug 18;7(8). doi: 10.3390/nano7080225.

Tuning Properties of Iron Oxide Nanoparticles in Aqueous Synthesis without Ligands to Improve MRI Relaxivity and SAR.

Nanomaterials (Basel, Switzerland)

Debora Bonvin, Duncan T L Alexander, Angel Millán, Rafael Piñol, Beatriz Sanz, Gerardo F Goya, Abelardo Martínez, Jessica A M Bastiaansen, Matthias Stuber, Kurt J Schenk, Heinrich Hofmann, Marijana Mionić Ebersold

Affiliations

  1. Powder Technology Laboratory, Institute of Matesrials, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. [email protected].
  2. Interdisciplinary Centre for Electron Microscopy (CIME), Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. [email protected].
  3. Instituto de Ciencia de Materiales de Aragón, Universidad de Zaragoza, C/Pedro Cerbuna 10, 50009 Zaragoza, Spain. [email protected].
  4. Instituto de Ciencia de Materiales de Aragón, Universidad de Zaragoza, C/Pedro Cerbuna 10, 50009 Zaragoza, Spain. [email protected].
  5. Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Mariano Esquillor s/n, 50018 Zaragoza, Spain. [email protected].
  6. Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Mariano Esquillor s/n, 50018 Zaragoza, Spain. [email protected].
  7. Grupo de Electrónica de Potencia y Microelectrónica, I3A, Universidad de Zaragoza, 50018 Zaragoza, Spain. [email protected].
  8. Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland. [email protected].
  9. Center for Biomedical Imaging (CIBM), 1011 Lausanne, Switzerland. [email protected].
  10. Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland. [email protected].
  11. Center for Biomedical Imaging (CIBM), 1011 Lausanne, Switzerland. [email protected].
  12. CCC-IPSB, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. [email protected].
  13. Powder Technology Laboratory, Institute of Matesrials, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. [email protected].
  14. Powder Technology Laboratory, Institute of Matesrials, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland. [email protected].
  15. Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), 1011 Lausanne, Switzerland. [email protected].
  16. Center for Biomedical Imaging (CIBM), 1011 Lausanne, Switzerland. [email protected].

PMID: 28820442 PMCID: PMC5575707 DOI: 10.3390/nano7080225

Abstract

Aqueous synthesis without ligands of iron oxide nanoparticles (IONPs) with exceptional properties still remains an open issue, because of the challenge to control simultaneously numerous properties of the IONPs in these rigorous settings. To solve this, it is necessary to correlate the synthesis process with their properties, but this correlation is until now not well understood. Here, we study and correlate the structure, crystallinity, morphology, as well as magnetic, relaxometric and heating properties of IONPs obtained for different durations of the hydrothermal treatment that correspond to the different growth stages of IONPs upon initial co-precipitation in aqueous environment without ligands. We find that their properties were different for IONPs with comparable diameters. Specifically, by controlling the growth of IONPs from primary to secondary particles firstly by colloidal and then also by magnetic interactions, we control their crystallinity from monocrystalline to polycrystalline IONPs, respectively. Surface energy minimization in the aqueous environment along with low temperature treatment is used to favor nearly defect-free IONPs featuring superior properties, such as high saturation magnetization, magnetic volume, surface crystallinity, the transversal magnetic resonance imaging (MRI) relaxivity (up to

Keywords: MRI relaxivity; aqueous synthesis; hydrothermal treatment; iron oxide nanoparticles; magnetic nanoparticle; saturation magnetization; specific absorption rate

Conflict of interest statement

The authors declare no conflict of interest.

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