Display options
Cite
Schut C, Mochizuki H, Grossman SK, et al. Brain Processing of Contagious Itch in Patients with Atopic Dermatitis. Front Psychol. 2017;8:1267doi: 10.3389/fpsyg.2017.01267.
Schut, C., Mochizuki, H., Grossman, S. K., Lin, A. C., Conklin, C. J., Mohamed, F. B., Gieler, U., Kupfer, J., & Yosipovitch, G. (2017). Brain Processing of Contagious Itch in Patients with Atopic Dermatitis. Frontiers in psychology, 81267. https://doi.org/10.3389/fpsyg.2017.01267
Schut, Christina, et al. "Brain Processing of Contagious Itch in Patients with Atopic Dermatitis." Frontiers in psychology vol. 8 (2017): 1267. doi: https://doi.org/10.3389/fpsyg.2017.01267
Schut C, Mochizuki H, Grossman SK, Lin AC, Conklin CJ, Mohamed FB, Gieler U, Kupfer J, Yosipovitch G. Brain Processing of Contagious Itch in Patients with Atopic Dermatitis. Front Psychol. 2017 Jul 25;8:1267. doi: 10.3389/fpsyg.2017.01267. eCollection 2017. PMID: 28790959; PMCID: PMC5524890.
Copy Download .nbib Format: NLM
Share it on

Front Psychol. 2017 Jul 25;8:1267. doi: 10.3389/fpsyg.2017.01267. eCollection 2017.

Brain Processing of Contagious Itch in Patients with Atopic Dermatitis.

Frontiers in psychology

Christina Schut, Hideki Mochizuki, Shoshana K Grossman, Andrew C Lin, Christopher J Conklin, Feroze B Mohamed, Uwe Gieler, Joerg Kupfer, Gil Yosipovitch

Affiliations

  1. Institute of Medical Psychology, Justus-Liebig-UniversityGiessen, Germany.
  2. Department of Dermatology, Lewis Katz School of Medicine at Temple University, PhiladelphiaPA, United States.
  3. Department of Dermatology and Cutaneous Surgery and Miami Itch Center, Miller School of Medicine, University of Miami, MiamiFL, United States.
  4. Department of Radiology, Jefferson Integrated Magnetic Resonance Imaging Center, Thomas Jefferson University, PhiladelphiaPA, United States.
  5. Department of Dermatology, University Hospital of Giessen and MarburgGiessen, Germany.

PMID: 28790959 PMCID: PMC5524890 DOI: 10.3389/fpsyg.2017.01267

Abstract

Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching. This phenomenon is coined "Contagious itch" (CI). Due to the fact that CI is more profound in patients with the chronic itchy skin disease atopic dermatitis (AD), we believe that it is highly relevant to study brain processing of CI in this group. Knowledge on brain areas involved in CI in AD-patients can provide us with useful hints regarding non-invasive treatments that AD-patients could profit from when they are confronted with itch-inducing situations in daily life. Therefore, this study investigated the brain processing of CI in AD-patients. 11 AD-patients underwent fMRI scans during the presentation of an itch inducing experimental video (EV) and a non-itch inducing control video (CV). Perfusion based brain activity was measured using arterial spin labeling functional MRI. As expected, the EV compared to the CV led to an increase in itch and scratching (

Keywords: atopic dermatitis; contagious itch; functional MRI; orbitofrontal cortex; striatum; supplementary motor area

References

  1. J Neurophysiol. 2009 Nov;102(5):2657-66 - PubMed
  2. Acta Derm Venereol. 2009;89(1):57-63 - PubMed
  3. Clin Psychol Sci. 2016 Mar;4(2):312-319 - PubMed
  4. Nat Rev Neurosci. 2006 Dec;7(12):942-51 - PubMed
  5. Brain Lang. 2004 May;89(2):370-6 - PubMed
  6. Neuron. 2004 Apr 22;42(2):323-34 - PubMed
  7. Acta Derm Venereol. 2014 Jan;94(1):20-5 - PubMed
  8. Neurophysiol Clin. 2012 Oct;42(5):299-313 - PubMed
  9. Br J Dermatol. 2009 Nov;161(5):1072-80 - PubMed
  10. Curr Allergy Asthma Rep. 2008 Jul;8(4):306-11 - PubMed
  11. J Neurosci. 1991 Nov;11(11):3656-66 - PubMed
  12. J Invest Dermatol. 2015 Nov;135(11):2814-23 - PubMed
  13. Eur J Pain. 2006 Jul;10(5):473-8 - PubMed
  14. Brain Res Cogn Brain Res. 2005 May;23(2-3):448-52 - PubMed
  15. Handb Exp Pharmacol. 2015;226:57-70 - PubMed
  16. Eur J Pain. 2005 Aug;9(4):463-84 - PubMed
  17. Brain. 2006 Mar;129(Pt 3):564-83 - PubMed
  18. Pain. 2013 Oct;154(10):1989-98 - PubMed
  19. Int J Mol Sci. 2016 Mar 22;17 (3):425 - PubMed
  20. Clin Neurophysiol. 2015 Sep;126(9):1650-60 - PubMed
  21. J Eur Acad Dermatol Venereol. 2013 Feb;27(2):e239-42 - PubMed
  22. J Am Acad Dermatol. 1998 Aug;39(2 Pt 1):268-9 - PubMed
  23. Acta Derm Venereol. 2012 Jan;92(1):57-61 - PubMed
  24. Allergol Int. 2017 Jan;66(1):14-21 - PubMed
  25. Curr Biol. 2006 Oct 10;16(19):1905-10 - PubMed
  26. Neuroimage. 2012 Feb 15;59(4):3611-23 - PubMed
  27. Int J Behav Med. 2015 Dec;22(6):726-34 - PubMed
  28. Eur J Pain. 2016 Jan;20(1):14-8 - PubMed
  29. Clin J Pain. 2013 Jul;29(7):621-2 - PubMed
  30. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19816-21 - PubMed
  31. Pain. 2007 Sep;131(1-2):4-7 - PubMed
  32. J Neurosci. 2010 Aug 11;30(32):10799-808 - PubMed
  33. Front Hum Neurosci. 2015 Feb 11;9:57 - PubMed
  34. Eur J Pain. 2008 Oct;12 (7):834-41 - PubMed
  35. Br J Dermatol. 2011 Jun;164(6):1299-303 - PubMed
  36. Psychopharmacology (Berl). 2006 Mar;184(3-4):577-88 - PubMed
  37. J Neurosci. 2011 Jul 20;31(29):10701-11 - PubMed
  38. Br J Dermatol. 2013 Jan;168(1):106-11 - PubMed
  39. PLoS One. 2011 Mar 14;6(3):e17786 - PubMed

Publication Types