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Asmah RH, Yeboah G, Asare-Anane H, et al. Relationship between oxidative stress and haematological indices in patients with diabetes in the Ghanaian population. Clin Diabetes Endocrinol. 2015;1:7doi: 10.1186/s40842-015-0008-2.
Asmah, R. H., Yeboah, G., Asare-Anane, H., Antwi-Baffour, S., Archampong, T. N., Brown, C. A., Amegatcher, G., Adjei, D. N., Dzudzor, B., Akpalu, J., & Ayeh-Kumi, P. F. (2015). Relationship between oxidative stress and haematological indices in patients with diabetes in the Ghanaian population. Clinical diabetes and endocrinology, 17. https://doi.org/10.1186/s40842-015-0008-2
Asmah, R H, et al. "Relationship between oxidative stress and haematological indices in patients with diabetes in the Ghanaian population." Clinical diabetes and endocrinology vol. 1 (2015): 7. doi: https://doi.org/10.1186/s40842-015-0008-2
Asmah RH, Yeboah G, Asare-Anane H, Antwi-Baffour S, Archampong TN, Brown CA, Amegatcher G, Adjei DN, Dzudzor B, Akpalu J, Ayeh-Kumi PF. Relationship between oxidative stress and haematological indices in patients with diabetes in the Ghanaian population. Clin Diabetes Endocrinol. 2015 Aug 20;1:7. doi: 10.1186/s40842-015-0008-2. eCollection 2015. PMID: 28702226; PMCID: PMC5471723.
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Clin Diabetes Endocrinol. 2015 Aug 20;1:7. doi: 10.1186/s40842-015-0008-2. eCollection 2015.

Relationship between oxidative stress and haematological indices in patients with diabetes in the Ghanaian population.

Clinical diabetes and endocrinology

R H Asmah, G Yeboah, H Asare-Anane, S Antwi-Baffour, T N Archampong, C A Brown, G Amegatcher, D N Adjei, B Dzudzor, J Akpalu, P F Ayeh-Kumi

Affiliations

  1. Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, University of Ghana, Korle-bu, Accra, Ghana.
  2. Department of Chemical Pathology, School of Biomedical and Allied Health Sciences, University of Ghana, Korle-bu, Accra, Ghana.
  3. Department of Medicine, School of Medicine and Dentistry, Korle-bu, Accra, Ghana.
  4. Department of Medical Biochemistry, School of Biomedical and Allied Health Sciences, University of Ghana, Korle-bu, Accra, Ghana.

PMID: 28702226 PMCID: PMC5471723 DOI: 10.1186/s40842-015-0008-2

Abstract

BACKGROUND: Persistent hyperglycaemia is a hallmark of Diabetes Mellitus (DM). It causes increased production of free radicals, especially reactive oxygen species (ROS), - resulting in oxidative stress. Reactive Oxygen Species have been implicated in the development of haematological complications in patients with diabetes. Superoxide Dismutase (SOD) is one of the most effective antioxidant enzyme defense systems against free radicals.

METHODS: From February through May 2014, we assessed the relationship between oxidative stress and haematological profiles among individuals with and without diabetes. A cross sectional study of 66 case patients and 44 age-matched controls were recruited from the National Diabetes Management and Research Centre (NDMRC), Korle-Bu Teaching Hospital, Accra, Ghana. Blood samples were obtained from study participants with consent. We determined the haematological profiles of study participants and measured their oxidative stress levels using a standardized kit for SOD activity.

RESULTS: Higher white blood cell (WBC) counts were seen in the diabetes cohort (

CONCLUSION: The study reports similar oxidative stress levels, as measured by SOD activity, in diabetic and non-diabetic adults. The SOD activity did not appear to correlate with FBG and several other haematological parameters. Further study would be required to investigate the relationship between these haematological indices and diabetic micro- and macro-vascular complications in our population.

Keywords: Diabetes Mellitus; Haematological parameters; Reactive oxygen species; Superoxide dismutase

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