Display options
Cite
Kruspe S, Giangrande PH. Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects. Biomedicines. 2017;5(3)doi: 10.3390/biomedicines5030045.
Kruspe, S., & Giangrande, P. H. (2017). Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects. Biomedicines, 5(3), . https://doi.org/10.3390/biomedicines5030045
Kruspe, Sven, and Giangrande, Paloma H. "Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects." Biomedicines vol. 5,3 (2017). doi: https://doi.org/10.3390/biomedicines5030045
Kruspe S, Giangrande PH. Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects. Biomedicines. 2017 Aug 09;5(3). doi: 10.3390/biomedicines5030045. PMID: 28792479; PMCID: PMC5618303.
Copy Download .nbib Format: NLM
Share it on

Biomedicines. 2017 Aug 09;5(3). doi: 10.3390/biomedicines5030045.

Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects.

Biomedicines

Sven Kruspe, Paloma H Giangrande

Affiliations

  1. Internal Medicine, University of Iowa, Iowa City, IA 52242, USA. [email protected].
  2. Internal Medicine, University of Iowa, Iowa City, IA 52242, USA. [email protected].
  3. Molecular & Cellular Biology Program, Holden Comprehensive Cancer Center, Radiation Oncology, Abboud Cardiovascular Research Center, and Environmental Health Sciences Research Center (EHSRC), University of Iowa, Iowa City, IA 52242, USA. [email protected].

PMID: 28792479 PMCID: PMC5618303 DOI: 10.3390/biomedicines5030045

Abstract

Synthetic nucleic acid ligands (aptamers) have emerged as effective delivery tools for many therapeutic oligonucleotide-based drugs, including small interfering RNAs (siRNAs). In this review, we summarize recent progress in the aptamer selection technology that has made possible the identification of cell-specific, cell-internalizing aptamers for the cell-targeted delivery of therapeutic oligonucleotides. In addition, we review the original, proof-of-concept aptamer-siRNA delivery studies and discuss recent advances in aptamer-siRNA conjugate designs for applications ranging from cancer therapy to the development of targeted antivirals. Challenges and prospects of aptamer-targeted siRNA drugs for clinical development are further highlighted.

Keywords: RNA interference; aptamers; targeted therapy

Conflict of interest statement

The authors declare no conflict of interest.

References

  1. J Leukoc Biol. 1999 Feb;65(2):151-61 - PubMed
  2. J Biol Chem. 1999 Sep 10;274(37):26369-77 - PubMed
  3. Blood. 2002 Feb 1;99(3):1023-9 - PubMed
  4. Nat Rev Mol Cell Biol. 2003 Jan;4(1):33-45 - PubMed
  5. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 - PubMed
  6. EMBO J. 1992 Oct;11(10):3767-75 - PubMed
  7. Cancer Res. 2003 Nov 1;63(21):7483-9 - PubMed
  8. Hum Gene Ther. 2005 Sep;16(9):1097-109 - PubMed
  9. Nano Lett. 2005 Sep;5(9):1797-808 - PubMed
  10. Biochem Pharmacol. 2006 Feb 28;71(5):702-10 - PubMed
  11. J Nucl Med. 2006 Apr;47(4):668-78 - PubMed
  12. Nucleic Acids Res. 2006 Jun 01;34(10):e73 - PubMed
  13. Nat Biotechnol. 2006 Aug;24(8):1005-15 - PubMed
  14. Nature. 1990 Mar 29;344(6265):467-8 - PubMed
  15. Curr Opin Cell Biol. 2006 Dec;18(6):616-22 - PubMed
  16. Nature. 1990 Aug 30;346(6287):818-22 - PubMed
  17. Blood. 2007 Apr 1;109(7):3069-75 - PubMed
  18. J Control Release. 2007 Oct 8;122(3):385-91 - PubMed
  19. J Ocul Pharmacol Ther. 2007 Oct;23(5):452-66 - PubMed
  20. Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6579-84 - PubMed
  21. J Clin Invest. 2008 Jan;118(1):376-86 - PubMed
  22. Hepatology. 2008 Mar;47(3):919-28 - PubMed
  23. J Proteome Res. 2008 May;7(5):2133-9 - PubMed
  24. Nat Biotechnol. 2008 May;26(5):561-9 - PubMed
  25. Mol Ther. 2008 Aug;16(8):1481-9 - PubMed
  26. Nat Rev Cancer. 2008 Jun;8(6):473-80 - PubMed
  27. Chem Soc Rev. 2008 Jul;37(7):1375-84 - PubMed
  28. Curr Cancer Drug Targets. 2008 Nov;8(7):554-65 - PubMed
  29. Oligonucleotides. 2008 Dec;18(4):305-19 - PubMed
  30. Clin Chem. 2009 Apr;55(4):813-22 - PubMed
  31. J Pathol. 2009 Jul;218(3):327-36 - PubMed
  32. Nucleic Acids Res. 2009 May;37(9):3094-109 - PubMed
  33. Expert Opin Ther Pat. 2009 Feb;19(2):137-40 - PubMed
  34. Exp Mol Pathol. 2009 Jun;86(3):151-64 - PubMed
  35. Nat Biotechnol. 2009 Sep;27(9):839-49 - PubMed
  36. Nat Biotechnol. 2009 Oct;27(10):925-32 - PubMed
  37. Nat Chem Biol. 2010 Jan;6(1):22-4 - PubMed
  38. Biomaterials. 2010 Jun;31(16):4592-9 - PubMed
  39. Nat Protoc. 2010 Jun;5(6):1169-85 - PubMed
  40. Nat Rev Drug Discov. 2010 Jul;9(7):537-50 - PubMed
  41. PLoS One. 2010 Sep 30;5(9):null - PubMed
  42. Sci Transl Med. 2011 Jan 19;3(66):66ra6 - PubMed
  43. J Clin Invest. 2011 Jun;121(6):2401-12 - PubMed
  44. PLoS One. 2011;6(6):e20299 - PubMed
  45. Surgery. 2011 Aug;150(2):224-30 - PubMed
  46. EMBO J. 2011 Aug 31;30(17):3481-500 - PubMed
  47. PLoS One. 2011;6(9):e24071 - PubMed
  48. ACS Nano. 2011 Oct 25;5(10):8131-9 - PubMed
  49. Science. 1990 Aug 3;249(4968):505-10 - PubMed
  50. Nat Rev Immunol. 2011 Nov 25;11(12):852-63 - PubMed
  51. Mol Cell Proteomics. 2012 Jun;11(6):M111.010744 - PubMed
  52. Mol Ther. 2012 Mar;20(3):525-33 - PubMed
  53. Science. 2012 Feb 17;335(6070):831-4 - PubMed
  54. Nucleic Acids Res. 2012 Jul;40(13):6319-37 - PubMed
  55. Cancer Invest. 2012 Oct;30(8):577-82 - PubMed
  56. Eur J Med Chem. 2012 Oct;56:396-9 - PubMed
  57. Mol Ther. 2012 Dec;20(12):2291-303 - PubMed
  58. PLoS One. 2012;7(9):e43836 - PubMed
  59. Mol Ther. 2013 Jan;21(1):192-200 - PubMed
  60. Cancer Lett. 2013 Mar 1;330(1):84-95 - PubMed
  61. Mol Ther Nucleic Acids. 2013 Jan 08;2:e67 - PubMed
  62. Mol Ther Nucleic Acids. 2012 Oct 16;1:e51 - PubMed
  63. PLoS One. 2013;8(2):e57613 - PubMed
  64. Nucleic Acid Ther. 2013 Jun;23(3):203-12 - PubMed
  65. APMIS. 2013 Oct;121(10):919-25 - PubMed
  66. PLoS One. 2013 Aug 13;8(8):e71798 - PubMed
  67. Sci Rep. 2013 Nov 07;3:3129 - PubMed
  68. J Clin Invest. 2014 Jan;124(1):188-97 - PubMed
  69. Ther Deliv. 2013 Dec;4(12):1527-46 - PubMed
  70. Biomaterials. 2014 Mar;35(9):2905-14 - PubMed
  71. Biomol Ther (Seoul). 2013 Nov;21(6):423-34 - PubMed
  72. Mol Ther. 2014 Jun;22(6):1151-1163 - PubMed
  73. Biomed Res Int. 2014;2014:849743 - PubMed
  74. J Pharm Biomed Anal. 2014 Dec;101:58-65 - PubMed
  75. J Clin Invest. 2014 Jul;124(7):2977-87 - PubMed
  76. Cell. 2014 Jun 5;157(6):1262-78 - PubMed
  77. Mol Ther Nucleic Acids. 2014 Jun 17;3:e169 - PubMed
  78. Mol Ther. 2014 Nov;22(11):1910-22 - PubMed
  79. Nat Rev Drug Discov. 2014 Jul;13(7):497-512 - PubMed
  80. ChemMedChem. 2014 Sep;9(9):1998-2011 - PubMed
  81. Methods Mol Biol. 2015;1218:187-99 - PubMed
  82. J Am Chem Soc. 2014 Dec 10;136(49):16958-61 - PubMed
  83. Adv Drug Deliv Rev. 2015 Jan;81:53-61 - PubMed
  84. Curr Gene Ther. 2015;15(2):109-19 - PubMed
  85. J Biomed Sci. 2015 Jan 09;22:4 - PubMed
  86. Adv Exp Med Biol. 2015;848:211-34 - PubMed
  87. Sci Signal. 2015 Mar 17;8(368):re3 - PubMed
  88. Chem Rev. 2015 Oct 14;115(19):11043-78 - PubMed
  89. Sci Rep. 2015 May 22;5:10326 - PubMed
  90. ACS Nano. 2015 Jun 23;9(6):6069-76 - PubMed
  91. Cancer Res. 2015 Aug 1;75(15):3077-86 - PubMed
  92. Front Oncol. 2015 Jun 08;5:117 - PubMed
  93. Nanomedicine (Lond). 2015 Jul;10(12):1863-79 - PubMed
  94. PLoS One. 2015 Jul 15;10(7):e0132407 - PubMed
  95. Nat Biotechnol. 2015 Aug;33(8):870-6 - PubMed
  96. Mol Cancer Ther. 2015 Oct;14(10):2279-91 - PubMed
  97. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11648-53 - PubMed
  98. Oncol Rep. 2015 Nov;34(5):2497-506 - PubMed
  99. Mol Ther Nucleic Acids. 2015 Oct 06;4:e254 - PubMed
  100. Biomacromolecules. 2016 Jan 11;17(1):76-87 - PubMed
  101. Theranostics. 2015 Oct 20;5(12):1456-72 - PubMed
  102. Mol Ther Nucleic Acids. 2016 Mar 15;5:e294 - PubMed
  103. Nat Rev Drug Discov. 2016 Apr;15(4):231 - PubMed
  104. Mol Ther Nucleic Acids. 2016 Mar 08;5:e289 - PubMed
  105. Br J Clin Pharmacol. 2016 Sep;82(3):659-72 - PubMed
  106. Sci Rep. 2016 Jun 06;6:27290 - PubMed
  107. J Control Release. 2016 Sep 28;238:43-57 - PubMed
  108. Sci Rep. 2016 Jul 26;6:30346 - PubMed
  109. Oxid Med Cell Longev. 2016;2016:7410257 - PubMed
  110. Neuropharmacology. 2017 Jul 1;120:4-7 - PubMed
  111. Mol Ther Nucleic Acids. 2016 Sep 20;5(9):e365 - PubMed
  112. Biochimie. 2016 Dec;131:77-84 - PubMed
  113. Mol Ther Nucleic Acids. 2016 Nov 1;5(10):e382 - PubMed
  114. Biotechniques. 2016 Nov 1;61(5):249-259 - PubMed
  115. Nucleic Acid Ther. 2017 Feb;27(1):1-3 - PubMed
  116. Int J Mol Sci. 2016 Dec 10;17(12): - PubMed
  117. Mol Ther. 2017 Jan 4;25(1):54-61 - PubMed
  118. Mol Ther Nucleic Acids. 2016;5:e345 - PubMed
  119. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):2125-2130 - PubMed
  120. Nanomaterials (Basel). 2017 Apr 05;7(4): - PubMed
  121. Transl Neurosci. 2017 Jan 26;8:1-6 - PubMed
  122. Theranostics. 2017 Mar 22;7(5):1360-1372 - PubMed
  123. Nat Rev Drug Discov. 2017 Jun;16(6):440 - PubMed
  124. Methods Mol Biol. 2017;1632:175-186 - PubMed
  125. Mol Ther Nucleic Acids. 2017 Dec 15;9:251-262 - PubMed
  126. Nature. 1994 Feb 17;367(6464):645-8 - PubMed
  127. Nucleic Acids Res. 1998 Sep 1;26(17):3915-24 - PubMed

Publication Types

Grant support