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Ren B, Chen C, Li C, et al. Optimization of microwave-assisted extraction of Sargassum thunbergii polysaccharides and its antioxidant and hypoglycemic activities. Carbohydr Polym. 2017;173:192-201doi: 10.1016/j.carbpol.2017.05.094.
Ren, B., Chen, C., Li, C., Fu, X., You, L., & Liu, R. H. (2017). Optimization of microwave-assisted extraction of Sargassum thunbergii polysaccharides and its antioxidant and hypoglycemic activities. Carbohydrate polymers, 173192-201. https://doi.org/10.1016/j.carbpol.2017.05.094
Ren, Beibei, et al. "Optimization of microwave-assisted extraction of Sargassum thunbergii polysaccharides and its antioxidant and hypoglycemic activities." Carbohydrate polymers vol. 173 (2017): 192-201. doi: https://doi.org/10.1016/j.carbpol.2017.05.094
Ren B, Chen C, Li C, Fu X, You L, Liu RH. Optimization of microwave-assisted extraction of Sargassum thunbergii polysaccharides and its antioxidant and hypoglycemic activities. Carbohydr Polym. 2017 Oct 01;173:192-201. doi: 10.1016/j.carbpol.2017.05.094. Epub 2017 Jun 03. PMID: 28732858.
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Carbohydr Polym. 2017 Oct 01;173:192-201. doi: 10.1016/j.carbpol.2017.05.094. Epub 2017 Jun 03.

Optimization of microwave-assisted extraction of Sargassum thunbergii polysaccharides and its antioxidant and hypoglycemic activities.

Carbohydrate polymers

Beibei Ren, Chun Chen, Chao Li, Xiong Fu, Lijun You, Rui Hai Liu

Affiliations

  1. School of Food Science and Engineering, South China University of Technology, 381Wushan Road, Guangzhou, 510640, PR China.
  2. School of Food Science and Engineering, South China University of Technology, 381Wushan Road, Guangzhou, 510640, PR China. Electronic address: [email protected].
  3. School of Food Science and Engineering, South China University of Technology, 381Wushan Road, Guangzhou, 510640, PR China. Electronic address: [email protected].
  4. School of Food Science and Engineering, South China University of Technology, 381Wushan Road, Guangzhou, 510640, PR China; Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY, 14853, USA.

PMID: 28732858 DOI: 10.1016/j.carbpol.2017.05.094

Abstract

In the present work, optimization of microwave-assisted extraction of polysaccharides from Sargassum thunbergii was investigated. The physicochemical properties, structural characteristics, and in vitro antioxidant and hypoglycemic activities were determined. The optimal extraction conditions with a yield of 2.84±0.09% for extraction of polysaccharides (STP-1) were extraction time 23min, microwave power 547W, extraction temperature 80°C, and the ratio of raw material to water 1:27g/mL. STP-1 contained 32.7% of total carbohydrate, 1.86% of protein, and 15.2% of sulfates. STP-1 had a major molecular weight of 190.4kDa, and comprised of arabinose, galactose, glucose, xylose, mannose, galacturonic acid, and glucuronic acid with molar percentages of 1.94, 30.7, 4.54, 23.2, 17.6, 8.11, and 13.9%, respectively. In addition, STP-1 showed strong antioxidant and α-glucosidase inhibitory activities, and could improve the glucose uptake in insulin-resistant HepG2 cells, suggesting that STP-1 can be exploited as a promising natural antioxidant and hypoglycemic agent.

Copyright © 2017 Elsevier Ltd. All rights reserved.

Keywords: Antioxidant; Hypoglycemic; Microwave extraction; Polysaccharides; Sargassum thunbergii

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