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Sci Immunol. 2017 May 12;2(11). doi: 10.1126/sciimmunol.aam7341.

Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.

Science immunology

Christina Guzzo, David Ichikawa, Chung Park, Damilola Phillips, Qingbo Liu, Peng Zhang, Alice Kwon, Huiyi Miao, Jacky Lu, Catherine Rehm, James Arthos, Claudia Cicala, Myron S Cohen, Anthony S Fauci, John H Kehrl, Paolo Lusso

Affiliations

  1. Viral Pathogenesis Section, Laboratory of Immunoregulation (LIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
  2. B-Cell Molecular Immunology Section, LIR, NIAID, NIH, Bethesda, MD 20892, USA.
  3. Clinical Research Section, LIR, NIAID, NIH, Bethesda, MD 20892, USA.
  4. Immunopathogenesis Section, LIR, NIAID, NIH, Bethesda, MD 20892, USA.
  5. Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  6. Viral Pathogenesis Section, Laboratory of Immunoregulation (LIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA. [email protected].

PMID: 28763793 PMCID: PMC5653278 DOI: 10.1126/sciimmunol.aam7341

Abstract

The intestinal mucosa is a key anatomical site for HIV-1 replication and CD4

Copyright © 2017, American Association for the Advancement of Science.

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