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Kalibatienė L, Kalibatas V, Macas A, et al. An evaluation of the effectiveness and safety of midazolam in children undergoing dental surgery. Medicina (Kaunas). 2015;51(3):180-186doi: 10.1016/j.medici.2015.04.001.
Kalibatienė, L., Kalibatas, V., Macas, A., & Trepenaitis, D. (2015). An evaluation of the effectiveness and safety of midazolam in children undergoing dental surgery. Medicina (Kaunas, Lithuania), 51(3), 180-186. https://doi.org/10.1016/j.medici.2015.04.001
Kalibatienė, Lina, et al. "An evaluation of the effectiveness and safety of midazolam in children undergoing dental surgery." Medicina (Kaunas, Lithuania) vol. 51,3 (2015): 180-186. doi: https://doi.org/10.1016/j.medici.2015.04.001
Kalibatienė L, Kalibatas V, Macas A, Trepenaitis D. An evaluation of the effectiveness and safety of midazolam in children undergoing dental surgery. Medicina (Kaunas). 2015;51(3):180-186. doi: 10.1016/j.medici.2015.04.001. Epub 2015 May 12. PMID: 28705481.
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Medicina (Kaunas). 2015;51(3):180-186. doi: 10.1016/j.medici.2015.04.001. Epub 2015 May 12.

An evaluation of the effectiveness and safety of midazolam in children undergoing dental surgery.

Medicina (Kaunas, Lithuania)

Lina Kalibatienė, Vytenis Kalibatas, Andrius Macas, Darius Trepenaitis

Affiliations

  1. Department of Anesthesiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: [email protected].
  2. Department of Health Management, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  3. Department of Anesthesiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

PMID: 28705481 DOI: 10.1016/j.medici.2015.04.001

Abstract

OBJECTIVE: The aim of this study was to evaluate the effectiveness and safety of oral midazolam in children undergoing dental surgery.

MATERIALS AND METHODS: A prospective, randomized, controlled trial was conducted to assess the effectiveness and safety of midazolam in children. Patients aged 2-9 years who underwent dental surgery under general anesthesia were randomly allocated into one of the four groups: midazolam 0.2mg/kg dose group (n=30); midazolam 0.21-0.4mg/kg dose group (n=15); midazolam more than 0.41mg/kg dose group (n=15) or the placebo group (n=31). The effectiveness of midazolam on sedation was assessed by the evaluation of vital signs, such as the respiratory and heart rate, oxygen saturation and the patients' reactive behaviors, in comparison with the placebo.

RESULTS: The scores of the ratings for sleep, movement and crying, as well as patients' reactions at the moment of separation from their parents and their collaboration with the staff were statistically significantly better among patients who received oral midazolam compared with the placebo. There were statistically significant direct correlations between the doses of midazolam and higher sleep, movement, crying and reaction scores 30min after premedication as well as higher scores of patients upon separation from their parents. There were only a few clinically insignificant side effects.

CONCLUSIONS: Oral midazolam, at a single dose from 0.2 to 0.6mg/kg, is effective and safe, and provides the expected sedative effects in children required by premedication for dental surgery.

Copyright © 2015 Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Keywords: Children; Dental surgery; Midazolam; Premedication

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