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Vallejo-Villalobos MF, León-Peña A, León-González M, et al. Primary Thrombophilia in México XI: Activated Protein C Resistance Phenotypes are Multifactorial. Indian J Hematol Blood Transfus. 2016;33(3):375-379doi: 10.1007/s12288-016-0767-7.
Vallejo-Villalobos, M. F., León-Peña, A., León-González, M., Núñez-Cortés, A. K., Olivares-Gazca, J. C., Valdés-Tapia, P., Garcés-Eisele, J., Ruiz-Argüelles, A., & Ruiz-Argüelles, G. J. (2017). Primary Thrombophilia in México XI: Activated Protein C Resistance Phenotypes are Multifactorial. Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 33(3), 375-379. https://doi.org/10.1007/s12288-016-0767-7
Vallejo-Villalobos, Ma Fernanda, et al. "Primary Thrombophilia in México XI: Activated Protein C Resistance Phenotypes are Multifactorial." Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion vol. 33,3 (2017): 375-379. doi: https://doi.org/10.1007/s12288-016-0767-7
Vallejo-Villalobos MF, León-Peña A, León-González M, Núñez-Cortés AK, Olivares-Gazca JC, Valdés-Tapia P, Garcés-Eisele J, Ruiz-Argüelles A, Ruiz-Argüelles GJ. Primary Thrombophilia in México XI: Activated Protein C Resistance Phenotypes are Multifactorial. Indian J Hematol Blood Transfus. 2017 Sep;33(3):375-379. doi: 10.1007/s12288-016-0767-7. Epub 2016 Dec 19. PMID: 28824240; PMCID: PMC5544651.
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Indian J Hematol Blood Transfus. 2017 Sep;33(3):375-379. doi: 10.1007/s12288-016-0767-7. Epub 2016 Dec 19.

Primary Thrombophilia in México XI: Activated Protein C Resistance Phenotypes are Multifactorial.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion

Ma Fernanda Vallejo-Villalobos, Andrés León-Peña, Mónica León-González, Ana Karen Núñez-Cortés, Juan Carlos Olivares-Gazca, Patricia Valdés-Tapia, Javier Garcés-Eisele, Alejandro Ruiz-Argüelles, Guillermo J Ruiz-Argüelles

Affiliations

  1. Laboratorios Clínicos de Puebla, Puebla, Mexico.
  2. Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico.
  3. Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
  4. Centro de Hematología y Medicina Interna de Puebla, 8B Sur 3710, 72530 Puebla, Mexico.
  5. Universidad de las Américas Puebla, Puebla, Mexico.

PMID: 28824240 PMCID: PMC5544651 DOI: 10.1007/s12288-016-0767-7

Abstract

Activated protein C resistance (aPCR) phenotypes represent around 20% of the laboratory findings in Mexican Mestizos having suffered thrombosis and displaying clinical markers of thrombophilia. In a single institution for a 276-month period, 96 Mexican mestizos with a history of thrombosis and clinical markers of a primary thrombophilic state were prospectively studied to identify a thrombophilic condition. An abnormal aPCR phenotype was identified in 18 individuals. Evaluation of those with an abnormal aPCR phenotype, identified that 44% had factor V Leiden mutation, 22% increased levels of factor VIII, 16% anti-phospholipid antibodies and 6% a lupus anticoagulant. In the remaining 22%, the use of direct oral anticoagulants (DOACs) in the past period of 12-24 h was recorded. We found significant associations between abnormal aPCR phenotype and the factor V Leiden mutation (

Keywords: Protein C; Resistance; Thrombophilia

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