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Zhang T, Chen T, Chen P, et al. MPTP-Induced Dopamine Depletion in Basolateral Amygdala . Front Mol Neurosci. 2017;10:247doi: 10.3389/fnmol.2017.00247.
Zhang, T., Chen, T., Chen, P., Zhang, B., Hong, J., & Chen, L. (2017). MPTP-Induced Dopamine Depletion in Basolateral Amygdala . Frontiers in molecular neuroscience, 10247. https://doi.org/10.3389/fnmol.2017.00247
Zhang, Tingting, et al. "MPTP-Induced Dopamine Depletion in Basolateral Amygdala ." Frontiers in molecular neuroscience vol. 10 (2017): 247. doi: https://doi.org/10.3389/fnmol.2017.00247
Zhang T, Chen T, Chen P, Zhang B, Hong J, Chen L. MPTP-Induced Dopamine Depletion in Basolateral Amygdala . Front Mol Neurosci. 2017 Aug 07;10:247. doi: 10.3389/fnmol.2017.00247. eCollection 2017. PMID: 28824377; PMCID: PMC5545577.
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Front Mol Neurosci. 2017 Aug 07;10:247. doi: 10.3389/fnmol.2017.00247. eCollection 2017.

MPTP-Induced Dopamine Depletion in Basolateral Amygdala .

Frontiers in molecular neuroscience

Tingting Zhang, Tingting Chen, Peipei Chen, Baofeng Zhang, Juan Hong, Ling Chen

Affiliations

  1. State Key Lab of Reproductive Medicine, Nanjing Medical UniversityNanjing, China.
  2. Department of Physiology, Nanjing Medical UniversityNanjing, China.

PMID: 28824377 PMCID: PMC5545577 DOI: 10.3389/fnmol.2017.00247

Abstract

Anxiety disorders commonly occur in Parkinson's disease. Using field potential recording and patch-clamp recording, we evaluated influence of MPTP-reduced dopaminergic afferent in basolateral amygdala (BLA), a main region for affective regulation, on excitatory-inhibitory circuits and synaptic plasticity. Field excitatory post-synaptic potential (fEPSP) slopes at external capsule-BLA synapses were increased in MPTP-mice with decreases in paired-pulse facilitation and long-term potentiation amplitude, which were corrected by bath-application of D2R agonist quinpirole or cannabinoid type 1 receptors agonist WIN55,212-2, but not D1R agonist SKF38393. Compared to single waveform fEPSP in control mice, a multi-spike waveform fEPSP was observed in MPTP-mice with prolongation of duration and an increase in paired-pulse inhibition, which were recovered by BLA-injection of quinpirole for 2 days rather than bath-application. Density of GABA-evoked current (

Keywords: GABAA receptor (GABAAR); anxiety-like behaviors; basolateral amygdala (BLA); dopaminergic receptor (DR); synaptic plasticity

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