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Blackwell RH, Foreman KE, Gupta GN. The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition. Cancers (Basel). 2017;9(8)doi: 10.3390/cancers9080105.
Blackwell, R. H., Foreman, K. E., & Gupta, G. N. (2017). The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition. Cancers, 9(8), . https://doi.org/10.3390/cancers9080105
Blackwell, Robert H, et al. "The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition." Cancers vol. 9,8 (2017). doi: https://doi.org/10.3390/cancers9080105
Blackwell RH, Foreman KE, Gupta GN. The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition. Cancers (Basel). 2017 Aug 10;9(8). doi: 10.3390/cancers9080105. PMID: 28796150; PMCID: PMC5575608.
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Cancers (Basel). 2017 Aug 10;9(8). doi: 10.3390/cancers9080105.

The Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition.

Cancers

Robert H Blackwell, Kimberly E Foreman, Gopal N Gupta

Affiliations

  1. Department of Urology, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153, USA. [email protected].
  2. Cardinal Bernardin Cancer Center, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153, USA. [email protected].
  3. Department of Urology, Loyola University Medical Center, 2160 S. First Ave., Maywood, IL 60153, USA. [email protected].

PMID: 28796150 PMCID: PMC5575608 DOI: 10.3390/cancers9080105

Abstract

Epithelial-to-mesenchymal transition (EMT) is a process by which epithelial cells lose their basement membrane interaction and acquire a more migratory, mesenchymal phenotype. EMT has been implicated in cancer cell progression, as cells transform and increase motility and invasiveness, induce angiogenesis, and metastasize. Exosomes are 30-100 nm membrane-bound vesicles that are formed and excreted by all cell types and released into the extracellular environment. Exosomal contents include DNA, mRNA, miRNA, as well as transmembrane- and membrane-bound proteins derived from their host cell contents. Exosomes are involved in intercellular signaling, both by membrane fusion to recipient cells with deposition of exosomal contents into the cytoplasm and by the binding of recipient cell membrane receptors. Recent work has implicated cancer-derived exosomes as an important mediator of intercellular signaling and EMT, with resultant transformation of cancer cells to a more aggressive phenotype, as well as the tropism of metastatic disease in specific cancer types with the establishment of the pre-metastatic niche.

Keywords: epithelial-mesenchymal transition; exosomes; intercellular signaling peptides and proteins; neoplasm invasiveness; neoplasm metastasis; neovascularization; pathologic

Conflict of interest statement

The authors declare no conflict of interest.

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