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Wang YY, Li HT, Lu Y, et al. [Protective effects of glycyrrhizic acid against lupus nephritis in MRL/lpr mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37(7):957-961
Wang, Y. Y., Li, H. T., Lu, Y., Jia, X. Y., Li, Y. L., Chen, S., Chai, J. X., Zhang, J. J., Liu, D., & Xie, C. H. (2017). [Protective effects of glycyrrhizic acid against lupus nephritis in MRL/lpr mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 37(7), 957-961.
Wang, Yuan-Yuan, et al. "[Protective effects of glycyrrhizic acid against lupus nephritis in MRL/lpr mice]." Nan fang yi ke da xue xue bao = Journal of Southern Medical University vol. 37,7 (2017): 957-961.
Wang YY, Li HT, Lu Y, Jia XY, Li YL, Chen S, Chai JX, Zhang JJ, Liu D, Xie CH. [Protective effects of glycyrrhizic acid against lupus nephritis in MRL/lpr mice]. Nan Fang Yi Ke Da Xue Xue Bao. 2017 Jul 20;37(7):957-961. Chinese. PMID: 28736376; PMCID: PMC6765503.
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Nan Fang Yi Ke Da Xue Xue Bao. 2017 Jul 20;37(7):957-961.

[Protective effects of glycyrrhizic acid against lupus nephritis in MRL/lpr mice].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[Article in Chinese]
Yuan-Yuan Wang, Hong-Tao Li, Yang Lu, Xiao-Yun Jia, Yang-Lei Li, Sheng Chen, Ji-Xia Chai, Jia-Jia Zhang, Dong Liu, Chang-Hao Xie

Affiliations

  1. Department of Histology and Embryology, Department of Clinical Medicine5, Bengbu Medical College, Anhui 233000, China.E-mail: [email protected].

PMID: 28736376 PMCID: PMC6765503

Abstract

OBJECTIVE: To investigate protective effect of glycyrrhizic acid (GA) against lupus nephritis in MRL/lpr mice and explore its underlying mechanisms.

METHODS: Forty MRL/lpr mice were randomized equally into blank control group, dexamethasone (1.5 mg/kg) group, GA (20 mg/kg) group, and GA (40 mg/kg) group with corresponding treatments for 7 days, with 10 wild-type mice as the control group. Serum levels of uric acid and creatinine and inflammatory cytokines in the serum and kidney were tested after the treatments using enzyme-linked immunosorbent assays (ELISA). The pathological changes in the kidneys were detected using HE staining, and the protein expressions of NLRP3, ASC, caspase-1, IL-1β, p-NF-κB, NF-κB, p-IκBα, and IκBα were detected with Western blotting.

RESULTS: GA obviously decreased serum levels of uric acid and creatinine, decreased inflammatory cytokines in the serum and kidney, ameliorated renal pathologies and inhibited the expressions of NLRP3, ASC, caspase-1, IL-1β, p-NF-κB, and p-IκBα proteins in MRL/lpr mice.

CONCLUSION: GA has protective effects against lupus nephritis in MRL/lpr mice.

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