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Gazdic M, Simovic Markovic B, Jovicic N, et al. Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response. Stem Cells Int. 2017;2017:6294717doi: 10.1155/2017/6294717.
Gazdic, M., Simovic Markovic, B., Jovicic, N., Misirkic-Marjanovic, M., Djonov, V., Jakovljevic, V., Arsenijevic, N., Lukic, M. L., & Volarevic, V. (2017). Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response. Stem cells international, 20176294717. https://doi.org/10.1155/2017/6294717
Gazdic, Marina, et al. "Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response." Stem cells international vol. 2017 (2017): 6294717. doi: https://doi.org/10.1155/2017/6294717
Gazdic M, Simovic Markovic B, Jovicic N, Misirkic-Marjanovic M, Djonov V, Jakovljevic V, Arsenijevic N, Lukic ML, Volarevic V. Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response. Stem Cells Int. 2017;2017:6294717. doi: 10.1155/2017/6294717. Epub 2017 Jul 16. PMID: 28798777; PMCID: PMC5534320.
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Stem Cells Int. 2017;2017:6294717. doi: 10.1155/2017/6294717. Epub 2017 Jul 16.

Mesenchymal Stem Cells Promote Metastasis of Lung Cancer Cells by Downregulating Systemic Antitumor Immune Response.

Stem cells international

Marina Gazdic, Bojana Simovic Markovic, Nemanja Jovicic, Maja Misirkic-Marjanovic, Valentin Djonov, Vladimir Jakovljevic, Nebojsa Arsenijevic, Miodrag L Lukic, Vladislav Volarevic

Affiliations

  1. Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
  2. Department of Microbiology and Immunology, Center for Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, 69 Svetozar Markovic Street, 34000 Kragujevac, Serbia.
  3. Department of Histology and Embryology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.
  4. Institute of Microbiology and Immunology, School of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  5. Institute of Anatomy, University of Bern, 3000 Bern 9, Switzerland.
  6. Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, Serbia.

PMID: 28798777 PMCID: PMC5534320 DOI: 10.1155/2017/6294717

Abstract

Since majority of systemically administered mesenchymal stem cells (MSCs) become entrapped within the lungs, we used metastatic model of lung cancer, induced by intravenous injection of Lewis lung cancer 1 (LLC1) cells, to investigate the molecular mechanisms involved in MSC-mediated modulation of metastasis. MSCs significantly augmented lung cancer metastasis, attenuate concentrations of proinflammatory cytokines (TNF-

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