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Dham SK, Anand AC, Dhananjayan G, et al. MICROSOMAL AND THYROGLOBULIN ANTIBODIES IN THYROID DISORDERS. Med J Armed Forces India. 2017;51(4):247-250doi: 10.1016/S0377-1237(17)30984-X.
Dham, S. K., Anand, A. C., Dhananjayan, G., & Shetty, K. J. (1995). MICROSOMAL AND THYROGLOBULIN ANTIBODIES IN THYROID DISORDERS. Medical journal, Armed Forces India, 51(4), 247-250. https://doi.org/10.1016/S0377-1237(17)30984-X
Dham, S K, et al. "MICROSOMAL AND THYROGLOBULIN ANTIBODIES IN THYROID DISORDERS." Medical journal, Armed Forces India vol. 51,4 (1995): 247-250. doi: https://doi.org/10.1016/S0377-1237(17)30984-X
Dham SK, Anand AC, Dhananjayan G, Shetty KJ. MICROSOMAL AND THYROGLOBULIN ANTIBODIES IN THYROID DISORDERS. Med J Armed Forces India. 1995 Oct;51(4):247-250. doi: 10.1016/S0377-1237(17)30984-X. Epub 2017 Jun 26. PMID: 28769306; PMCID: PMC5530228.
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Med J Armed Forces India. 1995 Oct;51(4):247-250. doi: 10.1016/S0377-1237(17)30984-X. Epub 2017 Jun 26.

MICROSOMAL AND THYROGLOBULIN ANTIBODIES IN THYROID DISORDERS.

Medical journal, Armed Forces India

S K Dham, A C Anand, G Dhananjayan, K J Shetty

Affiliations

  1. PMO, Western Air Command, C/o 56. APO.
  2. Reader, Dept of Medicine, Armed Forces Medical College, Pune 411 040.
  3. Classified Specialist Nuclear Medicine Army Hospital Delhi Cantt, New Delhi.
  4. Formerly Senior Consultant (Medicine), Office of The DGAFMS, New Delhi.

PMID: 28769306 PMCID: PMC5530228 DOI: 10.1016/S0377-1237(17)30984-X

Abstract

Eighty patients with various thyroid disorders and 20 controls were investigated to determine antibodies against thyroglobulin and microsomal antigens by haemagglutination and immunofluorescent techniques. They were also tested for immunoglobulin profile by radial immunodiffusion methods. Patients with Hashimoto's disease, idiopathic hypothyroidism, and Grave's disease showed significant elevations of IgG. None of the patients with toxic nodular goitre or thyroid adenoma showed any thyroid antibodies while 69.2% patients with Grave's disease, 16% with euthyroid goitre, 58.3% with hypothyroidism and all the patients with Hashimoto's disease had microsomal antibodies by immunofluorescent test. Similarly, all the cases of Hashimoto's disease, 41.6% of those with hypothyroidism, 30% of Grave's disease patients and none of the patients with toxic nodule or thyroid adenoma had thyroglobulin antibodies by haemaglutination test. Evaluation for auto-antibodies may aid the clinician in the overall assessment of various thyroid disorders.

Keywords: Autoantibodies; Microsomal antigen; Thyroglobulin

References

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