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Varma PP, Prasher PK, Madan H, et al. AZATHIOPRINE INDUCED BONE MARROW SUPPRESSION IN LIVE RELATED RENAL ALLOGRAFT RECIPIENTS. Med J Armed Forces India. 2017;52(1):45-47doi: 10.1016/S0377-1237(17)30834-1.
Varma, P. P., Prasher, P. K., Madan, H., & Yashpal, B. (1996). AZATHIOPRINE INDUCED BONE MARROW SUPPRESSION IN LIVE RELATED RENAL ALLOGRAFT RECIPIENTS. Medical journal, Armed Forces India, 52(1), 45-47. https://doi.org/10.1016/S0377-1237(17)30834-1
Varma, P P, et al. "AZATHIOPRINE INDUCED BONE MARROW SUPPRESSION IN LIVE RELATED RENAL ALLOGRAFT RECIPIENTS." Medical journal, Armed Forces India vol. 52,1 (1996): 45-47. doi: https://doi.org/10.1016/S0377-1237(17)30834-1
Varma PP, Prasher PK, Madan H, Yashpal B. AZATHIOPRINE INDUCED BONE MARROW SUPPRESSION IN LIVE RELATED RENAL ALLOGRAFT RECIPIENTS. Med J Armed Forces India. 1996 Jan;52(1):45-47. doi: 10.1016/S0377-1237(17)30834-1. Epub 2017 Jun 26. PMID: 28769336; PMCID: PMC5530283.
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Med J Armed Forces India. 1996 Jan;52(1):45-47. doi: 10.1016/S0377-1237(17)30834-1. Epub 2017 Jun 26.

AZATHIOPRINE INDUCED BONE MARROW SUPPRESSION IN LIVE RELATED RENAL ALLOGRAFT RECIPIENTS.

Medical journal, Armed Forces India

P P Varma, P K Prasher, H Madan, Brig Yashpal

Affiliations

  1. Nephrologists, Command Hospital (Southern Command), Pune.
  2. Physician Trainee, Command Hospital (Southern Command), Pune.
  3. Commandant, 151 Base Hospital, C/o 99 APO.

PMID: 28769336 PMCID: PMC5530283 DOI: 10.1016/S0377-1237(17)30834-1

Abstract

Over a follow-up period of 6 years, 4 out of 31 live related renal allograft recipients (12.9%) developed azathioprine induced bone marrow suppression. Presentation in 3 patients was with fever and 2 patients also had associated graft dysfunction. All patients had leucopenia, 2 patients in addition had anaemia and one patient had pancytopenia. Bone marrow suppression developed 9.6 months (3.5-16.0 months) following transplantation and recovery followed over a period of 30 (18-49 days) days after withdrawal of the drug. One patient succumbed during the phase of bicytopenia.

Keywords: Azathioprine; Bone marrow suppression; Kidney transplantation

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