Display options
Cite
Braniste T, Tiginyanu I, Horvath T, et al. Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles. Nanoscale Res Lett. 2017;12(1):486doi: 10.1186/s11671-017-2262-y.
Braniste, T., Tiginyanu, I., Horvath, T., Raevschi, S., Andrée, B., Cebotari, S., Boyle, E. C., Haverich, A., & Hilfiker, A. (2017). Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles. Nanoscale research letters, 12(1), 486. https://doi.org/10.1186/s11671-017-2262-y
Braniste, Tudor, et al. "Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles." Nanoscale research letters vol. 12,1 (2017): 486. doi: https://doi.org/10.1186/s11671-017-2262-y
Braniste T, Tiginyanu I, Horvath T, Raevschi S, Andrée B, Cebotari S, Boyle EC, Haverich A, Hilfiker A. Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles. Nanoscale Res Lett. 2017 Aug 10;12(1):486. doi: 10.1186/s11671-017-2262-y. PMID: 28799116; PMCID: PMC5552623.
Copy Download .nbib Format: NLM
Share it on

Nanoscale Res Lett. 2017 Aug 10;12(1):486. doi: 10.1186/s11671-017-2262-y.

Targeting Endothelial Cells with Multifunctional GaN/Fe Nanoparticles.

Nanoscale research letters

Tudor Braniste, Ion Tiginyanu, Tibor Horvath, Simion Raevschi, Birgit Andrée, Serghei Cebotari, Erin C Boyle, Axel Haverich, Andres Hilfiker

Affiliations

  1. National Center for Materials Study and Testing, Technical University of Moldova, Stefan cel Mare av. 168, MD-2004, Chisinau, Republic of Moldova.
  2. Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625, Hannover, Germany.
  3. Department of Physics and Engineering, State University of Moldova, str. Alexei Mateevici 60, Chisinau, MD-2009, Republic of Moldova.
  4. Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, D-30625, Hannover, Germany. [email protected].

PMID: 28799116 PMCID: PMC5552623 DOI: 10.1186/s11671-017-2262-y

Abstract

In this paper, we report on the interaction of multifunctional nanoparticles with living endothelial cells. The nanoparticles were synthesized using direct growth of gallium nitride on zinc oxide nanoparticles alloyed with iron oxide followed by core decomposition in hydrogen flow at high temperature. Using transmission electron microscopy, we demonstrate that porcine aortic endothelial cells take up GaN-based nanoparticles suspended in the growth medium. The nanoparticles are deposited in vesicles and the endothelial cells show no sign of cellular damage. Intracellular inert nanoparticles are used as guiding elements for controlled transportation or designed spatial distribution of cells in external magnetic fields.

Keywords: Cell guiding; Encapsulation; Endothelial cells; Gallium nitride; Nanoparticles

References

  1. Sci Rep. 2015 Mar 06;5:8839 - PubMed
  2. Nat Nanotechnol. 2010 Apr;5(4):291-6 - PubMed
  3. Int J Nanomedicine. 2008;3(2):133-49 - PubMed
  4. Beilstein J Nanotechnol. 2016 Sep 23;7:1330-1337 - PubMed
  5. ACS Nano. 2015 Sep 22;9(9):8655-71 - PubMed
  6. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2942-7 - PubMed
  7. Tissue Eng Part A. 2014 Feb;20(3-4):799-809 - PubMed
  8. Nat Commun. 2015 Aug 18;6:8009 - PubMed
  9. Physiol Rev. 2004 Oct;84(4):1341-79 - PubMed
  10. Sci Rep. 2016 Feb 15;6:20867 - PubMed

Publication Types