Display options
Cite
Milosevic ZC, Nadrljanski MM, Milovanovic ZM, et al. Breast Dynamic Contrast Enhanced MRI: Fibrocystic Changes Presenting as a Non-mass Enhancement Mimicking Malignancy. Radiol Oncol. 2017;51(2):130-136doi: 10.1515/raon-2017-0016.
Milosevic, Z. C., Nadrljanski, M. M., Milovanovic, Z. M., Gusic, N. Z., Vucicevic, S. S., & Radulovic, O. S. (2017). Breast Dynamic Contrast Enhanced MRI: Fibrocystic Changes Presenting as a Non-mass Enhancement Mimicking Malignancy. Radiology and oncology, 51(2), 130-136. https://doi.org/10.1515/raon-2017-0016
Milosevic, Zorica C, et al. "Breast Dynamic Contrast Enhanced MRI: Fibrocystic Changes Presenting as a Non-mass Enhancement Mimicking Malignancy." Radiology and oncology vol. 51,2 (2017): 130-136. doi: https://doi.org/10.1515/raon-2017-0016
Milosevic ZC, Nadrljanski MM, Milovanovic ZM, Gusic NZ, Vucicevic SS, Radulovic OS. Breast Dynamic Contrast Enhanced MRI: Fibrocystic Changes Presenting as a Non-mass Enhancement Mimicking Malignancy. Radiol Oncol. 2017 May 07;51(2):130-136. doi: 10.1515/raon-2017-0016. eCollection 2017 Jun. PMID: 28740447; PMCID: PMC5514652.
Copy Download .nbib Format: NLM
Share it on

Radiol Oncol. 2017 May 07;51(2):130-136. doi: 10.1515/raon-2017-0016. eCollection 2017 Jun.

Breast Dynamic Contrast Enhanced MRI: Fibrocystic Changes Presenting as a Non-mass Enhancement Mimicking Malignancy.

Radiology and oncology

Zorica C Milosevic, Mirjan M Nadrljanski, Zorka M Milovanovic, Nina Z Gusic, Slavko S Vucicevic, Olga S Radulovic

Affiliations

  1. Clinic for Radiation Oncology and Radiology, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia.
  2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  3. Department for Pathology, Institute of Oncology and Radiology of Serbia, Belgrade, Serbia.
  4. Primary Health Center Zvezdara, Belgrade, Serbia.
  5. Institute for Biological Research 'Sinisa Stankovic', Belgrade, Serbia.

PMID: 28740447 PMCID: PMC5514652 DOI: 10.1515/raon-2017-0016

Abstract

BACKGROUND: We aimed to analyse the morphokinetic features of breast fibrocystic changes (nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia) presenting as a non-mass enhancement (NME)in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) examination.

PATIENTS AND METHODS: Forty-six patients with histologically proven fibrocystic changes (FCCs) were retrospectively reviewed, according to Breast Imaging Reporting and Data System (BI-RADS) lexicon. Prior to DCE-MRI examination, a unilateral breast lesion suspicious of malignancy was detected clinically, on mammography or breast ultrasonography.

RESULTS: The predominant features of FCCs presenting as NME in DCE-MRI examination were: unilateral regional or diffuse distribution (in 35 patients or 76.1%), heterogeneous or clumped internal pattern of enhancement (in 36 patients or 78.3%), plateau time-intensity curve (in 25 patients or 54.3%), moderate or fast wash-in (in 31 patients or 67.4%).Nonproliferative lesions were found in 11 patients (24%), proliferative lesions without atypia in 29 patients (63%) and lesions with atypia in six patients (13%), without statistically significant difference of morphokinetic features, except of the association of clustered microcysts with proliferative dysplasia without atypia.

CONCLUSIONS: FCCs presenting as NME in DCE-MRI examination have several morphokinetic features suspicious of malignancy, therefore requiring biopsy (BI-RADS 4). Nonproliferative lesions, proliferative lesions without atypia and proliferative lesions with atypia predominantly share the same predefined DCE-MRI morphokinetic features.

Keywords: breast; fibrocystic changes; magnetic resonance imaging

Conflict of interest statement

Disclosure: No potential conflicts of interest were disclosed.

References

  1. Iran J Radiol. 2013 Jun;10(2):99-102 - PubMed
  2. Br J Radiol. 2012 Mar;85(1011):197-207 - PubMed
  3. J Magn Reson Imaging. 2007 Jan;25(1):104-12 - PubMed
  4. Bratisl Lek Listy. 2011;112(9):506-9 - PubMed
  5. Mod Pathol. 2010 May;23 Suppl 2:S1-7 - PubMed
  6. Epidemiol Rev. 1997;19(2):310-27 - PubMed
  7. Magn Reson Imaging. 2008 Nov;26(9):1207-14 - PubMed
  8. CA Cancer J Clin. 2007 Mar-Apr;57(2):75-89 - PubMed
  9. Cancer. 1993 Feb 15;71(4):1258-65 - PubMed
  10. Eur Radiol. 2010 Apr;20(4):771-81 - PubMed
  11. AJR Am J Roentgenol. 2006 Mar;186(3):865-70 - PubMed
  12. Oncologist. 2006 May;11(5):435-49 - PubMed
  13. Magn Reson Imaging Clin N Am. 2016 Feb;24(1):223-238 - PubMed
  14. J Magn Reson Imaging. 2008 Dec;28(6):1499-505 - PubMed
  15. Eur J Cancer. 2010 May;46(8):1296-316 - PubMed
  16. Cancer. 2009 Apr 1;115(7):1363-80 - PubMed
  17. Med Phys. 2008 Jul;35(7):3102-9 - PubMed
  18. Breast Cancer. 2013 Apr;20(2):137-44 - PubMed
  19. J Radiol. 2009 Mar;90(3 Pt 1):269-75 - PubMed
  20. N Engl J Med. 2005 Jul 21;353(3):275-85 - PubMed
  21. Eur J Radiol. 2010 Jul;75(1):e126-32 - PubMed
  22. AJR Am J Roentgenol. 2006 Aug;187(2):330-7 - PubMed
  23. Diagn Interv Radiol. 2013 Nov-Dec;19(6):463-70 - PubMed
  24. Invest Radiol. 2005 Jul;40(7):436-41 - PubMed
  25. Am J Epidemiol. 2004 Nov 15;160(10):945-60 - PubMed
  26. World J Surg Oncol. 2009 Jan 27;7:11 - PubMed
  27. N Engl J Med. 2015 Jan 1;372(1):78-89 - PubMed
  28. N Engl J Med. 1985 Jan 17;312(3):146-51 - PubMed

Publication Types