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Podrid PJ. Aggravation of Arrhythmia by Antiarrhythmic Drugs (Proarrhythmia). Card Electrophysiol Clin. 2010;2(3):459-470doi: 10.1016/j.ccep.2010.06.006.
Podrid, P. J. (2010). Aggravation of Arrhythmia by Antiarrhythmic Drugs (Proarrhythmia). Cardiac electrophysiology clinics, 2(3), 459-470. https://doi.org/10.1016/j.ccep.2010.06.006
Podrid, Philip J. "Aggravation of Arrhythmia by Antiarrhythmic Drugs (Proarrhythmia)." Cardiac electrophysiology clinics vol. 2,3 (2010): 459-470. doi: https://doi.org/10.1016/j.ccep.2010.06.006
Podrid PJ. Aggravation of Arrhythmia by Antiarrhythmic Drugs (Proarrhythmia). Card Electrophysiol Clin. 2010 Sep;2(3):459-470. doi: 10.1016/j.ccep.2010.06.006. PMID: 28770803.
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Card Electrophysiol Clin. 2010 Sep;2(3):459-470. doi: 10.1016/j.ccep.2010.06.006.

Aggravation of Arrhythmia by Antiarrhythmic Drugs (Proarrhythmia).

Cardiac electrophysiology clinics

Philip J Podrid

Affiliations

  1. Section of Cardiology, West Roxbury Veterans Administration Hospital, 1400 VFW Parkway, West Roxbury, MA 02132, USA.

PMID: 28770803 DOI: 10.1016/j.ccep.2010.06.006

Abstract

Arrhythmia aggravation by antiarrhythmic drugs (proarrhythmia) can be caused by worsening or a change of a preexisting arrhythmia, development of a new arrhythmia, or development of a bradyarrhythmia. Aggravation of arrhythmia usually occurs within several days of beginning an antiarrhythmic drug or increasing the dose of the drug. The time of occurrence is based on the particular drug and its pharmacokinetic properties. Although there are no ways to predict the patient at risk for developing arrhythmia aggravation with any specific agents, risk factors include QT interval prolongation, elevated serum levels of the drug, electrolyte abnormalities, presence of heart failure, a history of a sustained ventricular tachyarrhythmia, and underlying myocardial ischemia.

Copyright © 2010. Published by Elsevier Inc.

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