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Hotta H, Onda A, Suzuki H, et al. Modulation of Calcitonin, Parathyroid Hormone, and Thyroid Hormone Secretion by Electrical Stimulation of Sympathetic and Parasympathetic Nerves in Anesthetized Rats. Front Neurosci. 2017;11:375doi: 10.3389/fnins.2017.00375.
Hotta, H., Onda, A., Suzuki, H., Milliken, P., & Sridhar, A. (2017). Modulation of Calcitonin, Parathyroid Hormone, and Thyroid Hormone Secretion by Electrical Stimulation of Sympathetic and Parasympathetic Nerves in Anesthetized Rats. Frontiers in neuroscience, 11375. https://doi.org/10.3389/fnins.2017.00375
Hotta, Harumi, et al. "Modulation of Calcitonin, Parathyroid Hormone, and Thyroid Hormone Secretion by Electrical Stimulation of Sympathetic and Parasympathetic Nerves in Anesthetized Rats." Frontiers in neuroscience vol. 11 (2017): 375. doi: https://doi.org/10.3389/fnins.2017.00375
Hotta H, Onda A, Suzuki H, Milliken P, Sridhar A. Modulation of Calcitonin, Parathyroid Hormone, and Thyroid Hormone Secretion by Electrical Stimulation of Sympathetic and Parasympathetic Nerves in Anesthetized Rats. Front Neurosci. 2017 Jun 30;11:375. doi: 10.3389/fnins.2017.00375. eCollection 2017. PMID: 28713236; PMCID: PMC5491973.
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Front Neurosci. 2017 Jun 30;11:375. doi: 10.3389/fnins.2017.00375. eCollection 2017.

Modulation of Calcitonin, Parathyroid Hormone, and Thyroid Hormone Secretion by Electrical Stimulation of Sympathetic and Parasympathetic Nerves in Anesthetized Rats.

Frontiers in neuroscience

Harumi Hotta, Akiko Onda, Harue Suzuki, Philip Milliken, Arun Sridhar

Affiliations

  1. Department of Autonomic Neuroscience, Tokyo Metropolitan Institute of GerontologyTokyo, Japan.
  2. Galvani BioelectronicsStevenage, United Kingdom.

PMID: 28713236 PMCID: PMC5491973 DOI: 10.3389/fnins.2017.00375

Abstract

The thyroid and parathyroid glands are dually innervated by sympathetic (cervical sympathetic trunk [CST]) and parasympathetic (superior laryngeal nerve [SLN]) nerve fibers. We examined the effects of electrical stimulation of efferent or afferent nerve fibers innervating the thyroid and parathyroid glands on the secretion of immunoreactive calcitonin (iCT), parathyroid hormone (iPTH), 3,3',5-triiodothyronine (iT3), and thyroxine (iT4) from the thyroid and parathyroid glands. In anesthetized and artificially ventilated rats, thyroid venous blood was collected. The rate of hormone secretion from the glands was calculated from plasma hormone levels, measured by ELISA, and the flow rate of thyroid venous plasma. SLNs or CSTs were stimulated bilaterally with rectangular pulses with a 0.5-ms width. To define the role of unmyelinated nerve fibers (typically efferent), the cut peripheral segments were stimulated at various frequencies (up to 40 Hz) with a supramaximal intensity to excite all nerve fibers. The secretion of iCT, iT3, and iT4 increased during SLN stimulation and decreased during CST stimulation. iPTH secretion increased during CST stimulation, but was not affected by SLN stimulation. To examine the effects of selective stimulation of myelinated nerve fibers (typically afferent) in the SLN, intact SLNs were stimulated with a subthreshold intensity for unmyelinated nerve fibers. iCT, iT3, and iT4 secretion increased during stimulation of intact SLNs at 40 Hz. These results suggest that excitation of myelinated afferents induced by low intensity and high frequency stimulation of intact SLNs promotes secretion of CT and thyroid hormones from the thyroid gland, potentially via reflex activation of parasympathetic efferent nerve fibers in the SLN.

Keywords: calcitonin; cervical sympathetic trunk; electrical stimulation; parathyroid; parathyroid hormone; superior laryngeal nerve; thyroid

References

  1. Nat Rev Drug Discov. 2014 Jun;13(6):399-400 - PubMed
  2. J Bone Miner Metab. 2003;21(4):198-204 - PubMed
  3. Life Sci. 1983 Nov 7;33(19):1939-44 - PubMed
  4. Experientia. 1991 Oct 15;47(10):1067-9 - PubMed
  5. Nature. 2013 Apr 11;496(7444):159-61 - PubMed
  6. J Vet Med Sci. 1997 Jun;59(6):499-501 - PubMed
  7. J Physiol Sci. 2015 Jan;65(1):1-9 - PubMed
  8. Auton Neurosci. 2000 Sep 1;83(1-2):66-74 - PubMed
  9. J Auton Nerv Syst. 1994 Jun;48(1):45-53 - PubMed
  10. Acta Anat (Basel). 1976;96(2):206-17 - PubMed
  11. Endocrinology. 1968 Jan;82(1):7-16 - PubMed
  12. Daru. 2017 Feb 7;25(1):2 - PubMed
  13. J Anat. 2011 Aug;219(2):217-28 - PubMed
  14. Braz J Med Biol Res. 1994 Mar;27(3):573-99 - PubMed
  15. J Physiol Sci. 2008 Apr;58(2):133-8 - PubMed
  16. Am J Physiol. 1997 Jul;273(1 Pt 2):H234-43 - PubMed
  17. Auton Neurosci. 2012 Nov 2;171(1-2):14-20 - PubMed
  18. Jpn J Physiol. 1987;37(6):1005-17 - PubMed
  19. Endocrinology. 1983 Jul;113(1):379-84 - PubMed
  20. J Physiol. 1978 Sep;282:353-64 - PubMed
  21. Arch Gerontol Geriatr. 1988 Sep;7(3):229-38 - PubMed
  22. J Auton Nerv Syst. 1996 Jul 5;59(3):151-8 - PubMed
  23. Neurology. 2005 Jul 26;65(2):317-9 - PubMed
  24. Endocr Metab Immune Disord Drug Targets. 2006 Mar;6(1):59-76 - PubMed
  25. J Physiol. 1964 Dec;175:321-57 - PubMed
  26. Neurosci Lett. 1996 Nov 15;219(1):49-52 - PubMed
  27. Auton Neurosci. 2015 Jan;187:27-35 - PubMed
  28. Endocrinology. 1985 May;116(5):1977-82 - PubMed
  29. Neurology. 1998 Jul;51(1):48-55 - PubMed
  30. Curr Osteoporos Rep. 2016 Oct;14(5):226-38 - PubMed
  31. Jpn J Physiol. 1991;41(1):75-84 - PubMed
  32. Acta Otolaryngol. 1989 Nov-Dec;108(5-6):469-77 - PubMed

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