Display options
Cite
Barone P, Erro R, Picillo M. Quality of Life and Nonmotor Symptoms in Parkinson's Disease. Int Rev Neurobiol. 2017;133:499-516doi: 10.1016/bs.irn.2017.05.023.
Barone, P., Erro, R., & Picillo, M. (2017). Quality of Life and Nonmotor Symptoms in Parkinson's Disease. International review of neurobiology, 133499-516. https://doi.org/10.1016/bs.irn.2017.05.023
Barone, Paolo, et al. "Quality of Life and Nonmotor Symptoms in Parkinson's Disease." International review of neurobiology vol. 133 (2017): 499-516. doi: https://doi.org/10.1016/bs.irn.2017.05.023
Barone P, Erro R, Picillo M. Quality of Life and Nonmotor Symptoms in Parkinson's Disease. Int Rev Neurobiol. 2017;133:499-516. doi: 10.1016/bs.irn.2017.05.023. Epub 2017 Jul 15. PMID: 28802930.
Copy Download .nbib Format: NLM
Share it on

Int Rev Neurobiol. 2017;133:499-516. doi: 10.1016/bs.irn.2017.05.023. Epub 2017 Jul 15.

Quality of Life and Nonmotor Symptoms in Parkinson's Disease.

International review of neurobiology

Paolo Barone, Roberto Erro, Marina Picillo

Affiliations

  1. Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, University of Salerno, Salerno, Italy. Electronic address: [email protected].
  2. Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, University of Salerno, Salerno, Italy; University College London, Institute of Neurology, London, United Kingdom.
  3. Center for Neurodegenerative Diseases (CEMAND), Neuroscience Section, University of Salerno, Salerno, Italy.

PMID: 28802930 DOI: 10.1016/bs.irn.2017.05.023

Abstract

Health-related quality of life (HRQoL) is defined as "the perception and evaluation by patients themselves of the impact caused on their lives by the disease and its consequences." HRQoL is conceptualized as a combination of physical, psychological, and social well-being in the context of a particular disease. Following earlier studies revolving on the impact of the classic motor symptoms of Parkinson's disease on HRQoL, mounting evidence have been produced that nonmotor symptoms (NMS) significantly and independently contribute to worse HRQoL. This holds particularly true for such NMS such as neuropsychiatric disturbances, cognitive impairment, and fatigue, the burden of which might well exceed the effects of the motor symptoms. Nonetheless, there is very sparse evidence on how to manage these NMS and whether targeting NMS would in fact lead to an improvement of HRQoL, which calls for the need of future trials with NMS as primary outcomes.

© 2017 Elsevier Inc. All rights reserved.

Keywords: Nonmotor symptoms; Quality of life; Scales; Subtypes; Treatment; Well-being

MeSH terms

Publication Types